An improved process of separation of R- and S-timolol

Erika Várkonyi-Schlovicskó, Kálmán Takács, I. Hermecz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Diastereomeric timolol tartrates 4 are obtained in a one-pot synthesis from the racemic base 2 and optically active O,O-diacetyl- or O,O,- dibenzoyltartaric anhydrides 3, as only one of the diastereomers precipitates from acetone solution. Acidic hydrolysis as the corresponding 4 leads to timolol in high yield and optical purity.

Original languageEnglish
Pages (from-to)1065-1066
Number of pages2
JournalJournal of Heterocyclic Chemistry
Volume34
Issue number3
Publication statusPublished - 1997

Fingerprint

Timolol
Tartrates
Diacetyl
Anhydrides
Acetone
Precipitates
Hydrolysis

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Várkonyi-Schlovicskó, E., Takács, K., & Hermecz, I. (1997). An improved process of separation of R- and S-timolol. Journal of Heterocyclic Chemistry, 34(3), 1065-1066.

An improved process of separation of R- and S-timolol. / Várkonyi-Schlovicskó, Erika; Takács, Kálmán; Hermecz, I.

In: Journal of Heterocyclic Chemistry, Vol. 34, No. 3, 1997, p. 1065-1066.

Research output: Contribution to journalArticle

Várkonyi-Schlovicskó, E, Takács, K & Hermecz, I 1997, 'An improved process of separation of R- and S-timolol', Journal of Heterocyclic Chemistry, vol. 34, no. 3, pp. 1065-1066.
Várkonyi-Schlovicskó, Erika ; Takács, Kálmán ; Hermecz, I. / An improved process of separation of R- and S-timolol. In: Journal of Heterocyclic Chemistry. 1997 ; Vol. 34, No. 3. pp. 1065-1066.
@article{5c86ec97190447e7b41fa2128efb9d5f,
title = "An improved process of separation of R- and S-timolol",
abstract = "Diastereomeric timolol tartrates 4 are obtained in a one-pot synthesis from the racemic base 2 and optically active O,O-diacetyl- or O,O,- dibenzoyltartaric anhydrides 3, as only one of the diastereomers precipitates from acetone solution. Acidic hydrolysis as the corresponding 4 leads to timolol in high yield and optical purity.",
author = "Erika V{\'a}rkonyi-Schlovicsk{\'o} and K{\'a}lm{\'a}n Tak{\'a}cs and I. Hermecz",
year = "1997",
language = "English",
volume = "34",
pages = "1065--1066",
journal = "Journal of Heterocyclic Chemistry",
issn = "0022-152X",
publisher = "Heterocorporation",
number = "3",

}

TY - JOUR

T1 - An improved process of separation of R- and S-timolol

AU - Várkonyi-Schlovicskó, Erika

AU - Takács, Kálmán

AU - Hermecz, I.

PY - 1997

Y1 - 1997

N2 - Diastereomeric timolol tartrates 4 are obtained in a one-pot synthesis from the racemic base 2 and optically active O,O-diacetyl- or O,O,- dibenzoyltartaric anhydrides 3, as only one of the diastereomers precipitates from acetone solution. Acidic hydrolysis as the corresponding 4 leads to timolol in high yield and optical purity.

AB - Diastereomeric timolol tartrates 4 are obtained in a one-pot synthesis from the racemic base 2 and optically active O,O-diacetyl- or O,O,- dibenzoyltartaric anhydrides 3, as only one of the diastereomers precipitates from acetone solution. Acidic hydrolysis as the corresponding 4 leads to timolol in high yield and optical purity.

UR - http://www.scopus.com/inward/record.url?scp=0030795756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030795756&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030795756

VL - 34

SP - 1065

EP - 1066

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

SN - 0022-152X

IS - 3

ER -