An improved process of separation of R- and S-timolol

Erika Várkonyi-Schlovicskó, Kálmán Takács, István Hermecz

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Abstract

Diastereomeric timolol tartrates 4 are obtained in a one-pot synthesis from the racemic base 2 and optically active O,O-diacetyl- or O,O,- dibenzoyltartaric anhydrides 3, as only one of the diastereomers precipitates from acetone solution. Acidic hydrolysis as the corresponding 4 leads to timolol in high yield and optical purity.

Original languageEnglish
Pages (from-to)1065-1066
Number of pages2
JournalJournal of Heterocyclic Chemistry
Volume34
Issue number3
DOIs
Publication statusPublished - Jan 1 1997

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ASJC Scopus subject areas

  • Organic Chemistry

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