An immune-mediated guinea pig model for lower motor neuron disease

Josef Engelhardt, Ferenc Joo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Guinea pigs were immunized with motor neurons from swine spinal cords. One month after the last of five serial immunizations, the recipients showed progressive weight loss. By seven months of age, five of the six immunized animals had died. Pathological examination showed destruction of motor neurons in the spinal cords without demyelination, but with atrophy of the related skeletal muscle groups. By immunofluorescent and histochemical tests, serum from the guinea pigs was shown to react with motor neurons of swine and guinea pig cord. This experimental disorder of guinea pigs appeared to be based on the immunologically mediated destruction of motor neurons and it may serve as a model for the human motor neuron diseases.

Original languageEnglish
Pages (from-to)279-290
Number of pages12
JournalJournal of Neuroimmunology
Volume12
Issue number4
DOIs
Publication statusPublished - Oct 1986

Keywords

  • Animal model - Immunization - Isolated spinal motor neurons - Motor neuron disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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