An experimental vaccine for calf pneumonia caused by Mycoplasma bovis

Clinical, cultural, serological and pathological findings

Robin A J Nicholas, Roger D. Ayling, L. Stipkovits

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

A single dose of vaccine for Mycoplasma bovis pneumonia, inactivated with saponin, was inoculated subcutaneously into 3-4 week-old calves. The calves were challenged 3 weeks later with a virulent strain of M. bovis on two occasions within 24h using the aerosol route. The calves were monitored for clinical signs and serological responses then post mortemed 3 weeks after challenge. The vaccine was shown to be highly immunogenic in calves and did not cause adverse effects. Vaccinated calves showed few clinical signs while all unvaccinated calves developed signs of pneumonia. There was a significant decrease in body weight gain in unvaccinated calves compared to vaccinates and a significant increase in lung lesions and rectal temperatures in unvaccinated calves. The vaccine also reduced the spread of M. bovis to internal organs. In conclusion the M. bovis vaccine produced a significant level of protection against a large virulent challenge. Crown

Original languageEnglish
Pages (from-to)3569-3575
Number of pages7
JournalVaccine
Volume20
Issue number29-30
DOIs
Publication statusPublished - Oct 4 2002

Fingerprint

Mycoplasma bovis
pneumonia
Pneumonia
Vaccines
calves
vaccines
Mycoplasma Pneumonia
Saponins
Aerosols
Crowns
Weight Gain
Body Weight
Lung
Temperature
aerosols
saponins
lesions (animal)
adverse effects
lungs
weight gain

Keywords

  • Arthritis
  • Calf pneumonia
  • Mycoplasma bovis
  • Saponin

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

An experimental vaccine for calf pneumonia caused by Mycoplasma bovis : Clinical, cultural, serological and pathological findings. / Nicholas, Robin A J; Ayling, Roger D.; Stipkovits, L.

In: Vaccine, Vol. 20, No. 29-30, 04.10.2002, p. 3569-3575.

Research output: Contribution to journalArticle

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