An Experimental Study of a Concurrent Primary Infection with Bovine Respiratory Syncytial Virus (BRSV) and Bovine Viral Diarrhoea Virus (BVDV) in Calves

M. Elvander, C. Baule, M. Persson, L. Egyed, A. Ballagi-Pordány, S. Belák, S. Alenius

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Experimental infections with bovine respiratory syn- cytial virus (BRSV) and bovine viral diarrhoea virus (BVDV) were performed to study the effect of concurrent BRSV and BVDV infections. Twelve seronegative calves, in 3 groups, were inoculated on a single occasion with pure BRSV (group A), BRSV and noncytopathogenic BVDV (group B) or mock infected (group C). Mild respiratory symptoms were recorded 4 to 5 days post inoculation (dpi) in group A and group B calves. One calf in group A was severely affected and required medical treatment. In group B, fever (40.7-41.4 °C) was prominent 7 to 8 dpi. Only calves in group B were BVDV positive in purified lymphocytes at 2 to 14 dpi and showed increased serum interferon levels, with a peak at 4 dpi, indicating BVDV to be responsible for inducing the rise. BRSV was detected in lung lavage fluids up to 7 dpi for group A calves, compared to 11 dpi for group B and calves in this group also seroconverted later displaying lower BRSV titers. The time lag before an antibody response and the titers recorded in group B, indicated that the duration of BVDV infection in lymphocytes negatively influenced the capacity to mount a BRSV antibody response.

Original languageEnglish
Pages (from-to)251-264
Number of pages14
JournalActa Veterinaria Scandinavica
Volume39
Issue number2
Publication statusPublished - 1998

Fingerprint

Bovine respiratory syncytial virus
Bovine Viral Diarrhea Viruses
Bovine viral diarrhea virus
Cohort Studies
calves
Infection
infection
Virus Diseases
Antibody Formation
Pneumovirus
lymphocytes
Lymphocytes
antibodies
medical treatment
Bronchoalveolar Lavage Fluid
interferons
viral load
Viral Load
Interferons
signs and symptoms (animals and humans)

Keywords

  • Cattle
  • Interferon
  • PCR
  • Respiratory disease

ASJC Scopus subject areas

  • veterinary(all)

Cite this

An Experimental Study of a Concurrent Primary Infection with Bovine Respiratory Syncytial Virus (BRSV) and Bovine Viral Diarrhoea Virus (BVDV) in Calves. / Elvander, M.; Baule, C.; Persson, M.; Egyed, L.; Ballagi-Pordány, A.; Belák, S.; Alenius, S.

In: Acta Veterinaria Scandinavica, Vol. 39, No. 2, 1998, p. 251-264.

Research output: Contribution to journalArticle

Elvander, M. ; Baule, C. ; Persson, M. ; Egyed, L. ; Ballagi-Pordány, A. ; Belák, S. ; Alenius, S. / An Experimental Study of a Concurrent Primary Infection with Bovine Respiratory Syncytial Virus (BRSV) and Bovine Viral Diarrhoea Virus (BVDV) in Calves. In: Acta Veterinaria Scandinavica. 1998 ; Vol. 39, No. 2. pp. 251-264.
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