An Exception Within the Group of Autoimmune Blistering Diseases: Dermatitis Herpetiformis, the Gluten-Sensitive Dermopathy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Dermatitis herpetiformis (DH) is characterized by chronic, itching papules, seropapules, small vesicles and, exceptionally, large blisters. The distribution of these polymorphic symptoms around the elbow, knee, buttock, and back is suggestive of the diagnosis. DH is further confirmed by the accumulation of granulocytes at the papillary dermis, resulting in a subepidermal split formation and by the presence of a unique, granular IgA precipitate in the uppermost dermis. Prognosis is predominantly determined by other autoimmune pathologies, malabsorption, or very rarely by lymphomas. Some of these diseases can be prevented by an early-onset, strict gluten-free diet, which is therefore the suggested treatment option.

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalImmunology and Allergy Clinics of North America
Volume32
Issue number2
DOIs
Publication statusPublished - May 2012

Fingerprint

Dermatitis Herpetiformis
Glutens
Dermis
Autoimmune Diseases
Gluten-Free Diet
Buttocks
Blister
Pruritus
Elbow
Granulocytes
Immunoglobulin A
Lymphoma
Knee
Pathology
Therapeutics

Keywords

  • Dermatitis herpetiformis
  • Gluten sensitivity
  • IgA precipitate
  • Transglutaminase autoimmunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

@article{44fc34f26ddb4bebb82d174441cbeecd,
title = "An Exception Within the Group of Autoimmune Blistering Diseases: Dermatitis Herpetiformis, the Gluten-Sensitive Dermopathy",
abstract = "Dermatitis herpetiformis (DH) is characterized by chronic, itching papules, seropapules, small vesicles and, exceptionally, large blisters. The distribution of these polymorphic symptoms around the elbow, knee, buttock, and back is suggestive of the diagnosis. DH is further confirmed by the accumulation of granulocytes at the papillary dermis, resulting in a subepidermal split formation and by the presence of a unique, granular IgA precipitate in the uppermost dermis. Prognosis is predominantly determined by other autoimmune pathologies, malabsorption, or very rarely by lymphomas. Some of these diseases can be prevented by an early-onset, strict gluten-free diet, which is therefore the suggested treatment option.",
keywords = "Dermatitis herpetiformis, Gluten sensitivity, IgA precipitate, Transglutaminase autoimmunity",
author = "S. K{\'a}rp{\'a}ti",
year = "2012",
month = "5",
doi = "10.1016/j.iac.2012.04.005",
language = "English",
volume = "32",
pages = "255--262",
journal = "Immunology and Allergy Clinics of North America",
issn = "0889-8561",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - An Exception Within the Group of Autoimmune Blistering Diseases

T2 - Dermatitis Herpetiformis, the Gluten-Sensitive Dermopathy

AU - Kárpáti, S.

PY - 2012/5

Y1 - 2012/5

N2 - Dermatitis herpetiformis (DH) is characterized by chronic, itching papules, seropapules, small vesicles and, exceptionally, large blisters. The distribution of these polymorphic symptoms around the elbow, knee, buttock, and back is suggestive of the diagnosis. DH is further confirmed by the accumulation of granulocytes at the papillary dermis, resulting in a subepidermal split formation and by the presence of a unique, granular IgA precipitate in the uppermost dermis. Prognosis is predominantly determined by other autoimmune pathologies, malabsorption, or very rarely by lymphomas. Some of these diseases can be prevented by an early-onset, strict gluten-free diet, which is therefore the suggested treatment option.

AB - Dermatitis herpetiformis (DH) is characterized by chronic, itching papules, seropapules, small vesicles and, exceptionally, large blisters. The distribution of these polymorphic symptoms around the elbow, knee, buttock, and back is suggestive of the diagnosis. DH is further confirmed by the accumulation of granulocytes at the papillary dermis, resulting in a subepidermal split formation and by the presence of a unique, granular IgA precipitate in the uppermost dermis. Prognosis is predominantly determined by other autoimmune pathologies, malabsorption, or very rarely by lymphomas. Some of these diseases can be prevented by an early-onset, strict gluten-free diet, which is therefore the suggested treatment option.

KW - Dermatitis herpetiformis

KW - Gluten sensitivity

KW - IgA precipitate

KW - Transglutaminase autoimmunity

UR - http://www.scopus.com/inward/record.url?scp=84860483464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860483464&partnerID=8YFLogxK

U2 - 10.1016/j.iac.2012.04.005

DO - 10.1016/j.iac.2012.04.005

M3 - Article

C2 - 22560138

AN - SCOPUS:84860483464

VL - 32

SP - 255

EP - 262

JO - Immunology and Allergy Clinics of North America

JF - Immunology and Allergy Clinics of North America

SN - 0889-8561

IS - 2

ER -