An ether stressor increases REM sleep in rats: Possible role of prolactin

B. Bodosi, F. Obál, J. Gardi, J. Komlódi, J. Fang, J. M. Krueger

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Sleep alterations after a 1-min exposure to ether vapor were studied in rats to determine if this stressor increases rapid eye-movement (REM) sleep as does an immobilization stressor. Ether exposure before light onset or dark onset was followed by significant increases in REM sleep starting ~3-4 h later and lasting for several hours. Non-REM (NREM) sleep and electroencephalographic slow-wave activity during NREM sleep were not altered. Exposure to ether vapor elicited prolactin (Prl) secretion. REM sleep was not promoted after ether exposure in hypophysectomized rats. If the hypophysectomy was partial and the rats secreted Prl after ether exposure, then increases in REM sleep were observed. Intracerebroventricular administration of an antiserum to Prl decreased spontaneous REM sleep and inhibited ether exposure-induced REM sleep. The results indicate that a brief exposure to ether vapor is followed by increases in REM sleep if the Prl response associated with stress is unimpaired. This suggests that Prl, which is a previously documented REM sleep-promoting hormone, may contribute to the stimulation of REM sleep after ether exposure.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume279
Issue number5 48-5
Publication statusPublished - 2000

Fingerprint

REM Sleep
Prolactin
Ether
Sleep
Hypophysectomy
Eye Movements
Immobilization
Immune Sera
Hormones

Keywords

  • Hypophysectomy
  • Immunoneutralization
  • Pituitary

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

An ether stressor increases REM sleep in rats : Possible role of prolactin. / Bodosi, B.; Obál, F.; Gardi, J.; Komlódi, J.; Fang, J.; Krueger, J. M.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 279, No. 5 48-5, 2000.

Research output: Contribution to journalArticle

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