An epidemiological study of isolated split hand/foot in Hungary, 1975-1984

A. E. Czeizel, M. Vitez, I. Kodaj, W. Lenz

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A population based and validated 10 year cohort of 94 cases with split hand/foot born in Hungary, 1975-1984 was evaluated. This type of congenital limb deficiency was relatively frequently (43%) associated with non-limb defects. Fifty-four cases with isolated split hand/foot are evaluated in this paper. A single limb was affected in 78% of cases. The upper limbs were 21 times more frequently affected in unimelic cases with a right sided predominance and male excess. Case-control analysis indicated intrauterine growth retardation and lower socioeconomic status of parents of cases. Family study showed six familial cases with autosomal dominant inheritance among 152 first and 452 second degree relatives. All familial cases were males.

Original languageEnglish
Pages (from-to)593-596
Number of pages4
JournalJournal of medical genetics
Volume30
Issue number7
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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