An Energy Analysis of Extracellular Hyperthermia

A. Szasz, G. Vincze, O. Szasz, N. Szasz

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The classical hyperthermia effect is based on well-focused energy absorption targeting the malignant tissue. The treatment temperature has been considered as the main technical parameter. There are discussions about the mechanism and control of the process because of some doubts about the micro-mechanisms. The main idea of the extracellular hyperthermia is to heat up the targeted tissue by means of electric field, keeping the energy absorption in the extracellular liquid. This produces a temperature gradient and connected heat flow through the cell membrane, which initializes numerous nonequilibrium thermal microprocesses to destroy the cell membrane. Furthermore, before the heat shock activates the intracellular heat shock protein (HSP) mechanisms, the cell membrane has been already compromised, therefore the HSP synthesis in the cells starts secondarily only after the membrane damage. The process could explain why the nonuniform and basically unsatisfactorily high temperature locoregional hyperthermia could be effective.

Original languageEnglish
Pages (from-to)103-115
Number of pages13
JournalElectromagnetic Biology and Medicine
Volume22
Issue number2-3
DOIs
Publication statusPublished - Dec 1 2003

Keywords

  • Cell destruction
  • Heat-flow
  • Hyperthermia
  • Oncology

ASJC Scopus subject areas

  • Biophysics
  • Medicine (miscellaneous)

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