The ultrastructure of the NK/Ly mouse ascites lymphoma cell and the alterations caused by two alkylating agents, mannomustine (Degranol) and cyclophosphamide (Endoxan), are described. Cells were examined at different times following treatment in order to follow the degenerative and regenerative changes. NK/Ly lymphoma cells resemble both normal lymphoid cells and also other types of ascites cells. Treatment by the cytostatic drugs caused typical but not specific degenerative changes. During the recovery period larger cells, sometimes multinucleate with large rather empty mitochondria, appeared. Virus particles were found in the Golgi region of many cells, particularly after exposure to the drugs. These particles resemble oncogenic viruses, but their relation to these is obscure, and it has not yet proved possible to transfer the NK lymphoma by cell-free filtrates.
|Number of pages||6|
|Publication status||Published - Jun 1 1963|
ASJC Scopus subject areas
- Cancer Research