An Electron Microscope Study of NK Lymphoma Cells and the Changes Produced by Two Cytostatic Drugs

K. Lapis, E. H. Mercer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The ultrastructure of the NK/Ly mouse ascites lymphoma cell and the alterations caused by two alkylating agents, mannomustine (Degranol) and cyclophosphamide (Endoxan), are described. Cells were examined at different times following treatment in order to follow the degenerative and regenerative changes. NK/Ly lymphoma cells resemble both normal lymphoid cells and also other types of ascites cells. Treatment by the cytostatic drugs caused typical but not specific degenerative changes. During the recovery period larger cells, sometimes multinucleate with large rather empty mitochondria, appeared. Virus particles were found in the Golgi region of many cells, particularly after exposure to the drugs. These particles resemble oncogenic viruses, but their relation to these is obscure, and it has not yet proved possible to transfer the NK lymphoma by cell-free filtrates.

Original languageEnglish
Pages (from-to)676-681
Number of pages6
JournalCancer Research
Volume23
Issue number5
Publication statusPublished - Jun 1 1963

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Cytostatic Agents
Natural Killer Cells
Lymphoma
Electrons
Mannomustine
Ascites
Cyclophosphamide
Oncogenic Viruses
Alkylating Agents
Virion
Mitochondria
Lymphocytes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

An Electron Microscope Study of NK Lymphoma Cells and the Changes Produced by Two Cytostatic Drugs. / Lapis, K.; Mercer, E. H.

In: Cancer Research, Vol. 23, No. 5, 01.06.1963, p. 676-681.

Research output: Contribution to journalArticle

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