An efficient synthesis of γ-imino- and γ-amino-β-enamino esters

Sven Mangelinckx, Pieter Van Vooren, David De Clerck, Ferenc Fülöp, Norbert De Kimpe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Condensation of ethyl 3-azido-4-oxopentanoate, easily accessible from ethyl 3-chloro-4-oxopentanoate, with primary amines was found to produce ethyl 4-imino-3-amino-2-pentenoates. In addition, ethyl 4-imino-3-amino-2-pentenoates were reduced chemoselectively to the corresponding ethyl 4-alkylamino-3-amino-2- pentenoates upon hydrogenation.

Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalArkivoc
Volume2006
Issue number3
Publication statusPublished - Sep 12 2005

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Keywords

  • 1-aza-1,3-butadienes
  • Functionalized enamino esters
  • Functionalized ketimines
  • γ-amino esters

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Mangelinckx, S., Van Vooren, P., De Clerck, D., Fülöp, F., & De Kimpe, N. (2005). An efficient synthesis of γ-imino- and γ-amino-β-enamino esters. Arkivoc, 2006(3), 202-209.