An efficient new enzymatic method for the preparation of β-aryl-β-amino acid enantiomers

Gábor Tasnádi, E. Forró, F. Fülöp

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

An efficient synthesis of β-aryl-β-amino acid enantiomers has been developed via the lipase-catalysed enantioselective hydrolysis of the corresponding racemic ethyl esters in an organic solvent. High enantioselectivities (E >100) were observed when the lipase PS-catalysed reactions were performed with H2O (0.5 equiv) in diisopropyl ether at 45 °C. The products could be easily separated and were obtained in good yields of ≥40%.

Original languageEnglish
Pages (from-to)2072-2077
Number of pages6
JournalTetrahedron Asymmetry
Volume19
Issue number17
DOIs
Publication statusPublished - Sep 8 2008

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Enantiomers
enantiomers
Lipases
Lipase
amino acids
hydrolysis
Amino acids
esters
ethers
Amino Acids
preparation
Enantioselectivity
synthesis
products
Organic solvents
Hydrolysis
Ethers
Esters
diisopropyl ether

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

An efficient new enzymatic method for the preparation of β-aryl-β-amino acid enantiomers. / Tasnádi, Gábor; Forró, E.; Fülöp, F.

In: Tetrahedron Asymmetry, Vol. 19, No. 17, 08.09.2008, p. 2072-2077.

Research output: Contribution to journalArticle

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