An efficient new enzymatic method for the preparation of β-aryl-β-amino acid enantiomers

Gábor Tasnádi, Eniko Forró, Ferenc Fülöp

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33 Citations (Scopus)

Abstract

An efficient synthesis of β-aryl-β-amino acid enantiomers has been developed via the lipase-catalysed enantioselective hydrolysis of the corresponding racemic ethyl esters in an organic solvent. High enantioselectivities (E >100) were observed when the lipase PS-catalysed reactions were performed with H2O (0.5 equiv) in diisopropyl ether at 45 °C. The products could be easily separated and were obtained in good yields of ≥40%.

Original languageEnglish
Pages (from-to)2072-2077
Number of pages6
JournalTetrahedron Asymmetry
Volume19
Issue number17
DOIs
Publication statusPublished - Sep 8 2008

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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