An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect

Nadya Kaval, Beata Halasz-Dajka, Giang Vo-Thanh, Wim Dehaen, Johan Van Der Eycken, P. Mátyus, André Loupy, Erik Van Der Eycken

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Significant improvements in the synthesis of pyrido-fused heterocycles were observed when performing the reaction under solvent-free conditions, applying the tert-amino effect as the key ring closure methodology. An unexpected cyclization of ortho-(1′-azacycloalkyl)benzaldehydes has been studied in water and on solid support.

Original languageEnglish
Pages (from-to)9052-9057
Number of pages6
JournalTetrahedron
Volume61
Issue number38
DOIs
Publication statusPublished - Sep 19 2005

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Benzaldehydes
Cyclization
Microwaves
Water

Keywords

  • Microwave
  • Pyrido-fused
  • Solvent free
  • tert-Amino effect

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Kaval, N., Halasz-Dajka, B., Vo-Thanh, G., Dehaen, W., Van Der Eycken, J., Mátyus, P., ... Van Der Eycken, E. (2005). An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect. Tetrahedron, 61(38), 9052-9057. https://doi.org/10.1016/j.tet.2005.07.046

An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect. / Kaval, Nadya; Halasz-Dajka, Beata; Vo-Thanh, Giang; Dehaen, Wim; Van Der Eycken, Johan; Mátyus, P.; Loupy, André; Van Der Eycken, Erik.

In: Tetrahedron, Vol. 61, No. 38, 19.09.2005, p. 9052-9057.

Research output: Contribution to journalArticle

Kaval, N, Halasz-Dajka, B, Vo-Thanh, G, Dehaen, W, Van Der Eycken, J, Mátyus, P, Loupy, A & Van Der Eycken, E 2005, 'An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect', Tetrahedron, vol. 61, no. 38, pp. 9052-9057. https://doi.org/10.1016/j.tet.2005.07.046
Kaval, Nadya ; Halasz-Dajka, Beata ; Vo-Thanh, Giang ; Dehaen, Wim ; Van Der Eycken, Johan ; Mátyus, P. ; Loupy, André ; Van Der Eycken, Erik. / An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect. In: Tetrahedron. 2005 ; Vol. 61, No. 38. pp. 9052-9057.
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