An easy access to tetra-o-alkylated calix[4]arenes of cone conformation

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Abstract

Fully O-alkylated calix[4]arenes have been synthesized by the alkylation of p-tertbutylcalix[4]arene and its 1,3-dialkylated derivatives in liquid-liquid phase-transfer catalytic process. 1H4 and 1H2R2 could effeciently be deprotonated by aqueous NaOH (50% w/w)-toluene system and alkylated with alkyl (aralkyl, allyl) halogens in good yields affording calix[4]arene tetraethers of cone conformation.

Original languageEnglish
Pages (from-to)7835-7840
Number of pages6
JournalTetrahedron
Volume51
Issue number28
DOIs
Publication statusPublished - Jul 10 1995

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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