An early phase II trial with L-deprenyl for the treatment of neuroleptic-induced parkinsonism

A. Perenyi, G. Bagdy, M. Arato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of L-deprenyl on neuroleptic-induced parkinsonism was evaluated in eleven patients. No significant improvement was observed during the treatment with L-deprenyl in the overall assessment. Four patients, however, were considered responders, as their total scores on the modified version of the Neurological Rating Scale decreased by at least 50%. No somatic or mental complications were observed during the study. The pretreatment platelet monoamine oxidase activity of the responders was slightly but not significantly higher than that of the non-responders. The plasma prolactin (PRL) levels of the patients with high pretreatment levels decreased significantly during the administration of L-deprenyl.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalPharmacopsychiatria
Volume16
Issue number5
DOIs
Publication statusPublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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