An anti-CD3∈ serum detects T lymphocytes in paraffin-embedded pathological tissues in many animal species

G. Keresztes, R. Glávits, L. Krenács, É Kurucz, I. Andó

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Abstract

The in situ identification of T cells has been difficult and restricted to frozen tissue samples of a limited range of species. In this study, we demonstrate that an antiserum recognizing a phylogenetically conserved part of the CD3∈ cytoplasmic tail detects T cells of many avian and mammalian species in formalin-fixed paraffin-embedded tissue sections. This antiserum enables the morphological characterization of normal and pathological lymphoid tissues and lymphoid infiltrations in experimental work and in animal disease.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalImmunology letters
Volume50
Issue number3
DOIs
Publication statusPublished - May 1996

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Keywords

  • Avian and mammalian CD3∈
  • Formaldehyde fixation
  • Immunohistochemistry
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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