An Age-Associated Decrease in the Frequency of C4B*Q0 Indicates That Null Alleles of Complement May Affect Health or Survival

Gudmundur Jóhann Arason, Sigurdur Bödvarsson, Sigurdur Por Sigurdarson, Gardar Sigurdsson, Gudmundur Porgeirsson, Sveinn Gudmundsson, Judit Kramer, Georg Füst

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B*Q0) and C3 (C3*F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B*Q0 on health or survival.

Original languageEnglish
Pages (from-to)496-499
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume1010
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • C4B*Q0
  • Coronary artery disease
  • Hungary
  • Iceland

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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