An aetiological study of the VACTERL-association

E. Czeizel, I. Ludányi

Research output: Contribution to journalArticle

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Abstract

This paper reports the results of the first population-based study of the aetiology of VACTERL-association (i.e., the occurrence of three or more closely defined VACTERL-type abnormalities without other major congenital abnormalities). Forty-three VACTERL-associations and 33 VACTERL-like cases (the latter representing combinations of three or more closely or broadly defined VACTERL abnormalities with other congenital abnormalities) were evaluated. The noteworthy features of the VACTERL-association are: a significant male preponderance, a fetal weight retardation in full-term pregnancies, planned conceptions occurring later than in general and a higher incidence of infertility problems. Our data support the thesis that genetic factors are probably not involved in the aetiology of the VACTERL-association. In contrast, the VACTERL-like cases have a female excess, a higher rate of advanced birth order, no disturbance in fertility and some specific familial occurrence. These findings strongly suggest that genetic factors play a role in the aetiology of this heterogeneous group of multiple congenital abnormalities.

Original languageEnglish
Pages (from-to)331-337
Number of pages7
JournalEuropean Journal of Pediatrics
Volume144
Issue number4
DOIs
Publication statusPublished - Nov 1985

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Multiple Abnormalities
Fetal Weight
Birth Order
Family Planning Services
Infertility
Fertility
VACTERL association
Incidence
Population

Keywords

  • Delayed fertility
  • Epidemiologic features
  • Family study
  • VACTERL-association

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

An aetiological study of the VACTERL-association. / Czeizel, E.; Ludányi, I.

In: European Journal of Pediatrics, Vol. 144, No. 4, 11.1985, p. 331-337.

Research output: Contribution to journalArticle

Czeizel, E. ; Ludányi, I. / An aetiological study of the VACTERL-association. In: European Journal of Pediatrics. 1985 ; Vol. 144, No. 4. pp. 331-337.
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