An adamantane derivative(N-N'(1-adamantil)-ethylene diamine dibromide) induced automaticity in the ventricular myocardium of the frog

J. Meszaros, T. Kovacs, Z. Dinya, J. Szegi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of an adamantane derivative (N-N'(1-adamantil)-ethylene diamine dibromide; AED) on the transmembrane potentials and contractile activity of isolated electrically driven frog ventricular strips were studied. The effect of AED on the 42K efflux in ventricular muscle rings was also investigated. AED at a concentration of 10-3 N markedly markedley reduced the rate of depolarization and prolonged the duration of action potential. The resting potential was shifted to less negative potential ranges and pacemaker-like action potentials appeared within 10 minutes of exposure to the drug. AED was found to exert an enhancing effect on the contractile force of the frog ventricular muscle. The slow Ca2+-channel blocker D-600 was able to abolish completely the AED-induced automaticity, while the beta-adrenocepter blocker pindolol failed to prevent this action. The pacemaker activity was reduced by increasing external K+ concentration. AED markedly reduced the 42K efflux in ventricular muscle rings. In conclusion, the AED was shown to be able to induce automaticity by decreasing the outward movement of potassium ions and by depolarizing the cell membrane.

Original languageEnglish
Pages (from-to)79-87
Number of pages9
JournalActa physiologica Academiae Scientiarum Hungaricae
Volume58
Issue number1
Publication statusPublished - Dec 1 1981

ASJC Scopus subject areas

  • Physiology

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