An ab initio conformational study on captopril

Graciela N. Zamarbide, Mario R. Estrada, Miguel A. Zamora, Ladislaus L. Torday, Ricardo D. Enriz, Francisco Tomás Vert, Imre G. Csizmadia

Research output: Contribution to journalArticle

5 Citations (Scopus)


Captopril can interact regio- and stereo-specifically with various functional groups present at the active site of angiotensin converting enzyme (ACE). Since no X-ray structure of ACE is available, Captopril, as an ACE inhibitor may be used as a 'molecular caliper', to estimate upper and lower bound values for separation d, where the mercaptidic terminal group of the molecule is linked to the enzyme Zn2+ cofactor, while the carboxylate links via an hydrogen bond to the guanidine moiety of an arginine side chain. As the results of this Ab Initio study, the conformations of the dianionic form of the full captopril molecule are reported here.

Original languageEnglish
Pages (from-to)599-608
Number of pages10
JournalJournal of Molecular Structure: THEOCHEM
Publication statusPublished - Dec 29 2003


  • Antihypertensive drug
  • Captopril
  • Molecular caliper
  • Organic sulphur
  • Role of Zn cofactor

ASJC Scopus subject areas

  • Biochemistry
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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  • Cite this

    Zamarbide, G. N., Estrada, M. R., Zamora, M. A., Torday, L. L., Enriz, R. D., Vert, F. T., & Csizmadia, I. G. (2003). An ab initio conformational study on captopril. Journal of Molecular Structure: THEOCHEM, 666-667, 599-608.