An A > G polymorphism at position - 670 in the Fas (TNFRSF6) gene in pregnant women with pre-eclampsia and intrauterine growth restriction

I. Sziller, Daniel Nguyen, Amrita Halmos, P. Hupuczi, Z. Papp, Steven S. Witkin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fas-mediated apoptosis of maternal lymphocytes during pregnancy has been postulated to prevent the development of pre-eclampsia. A single adenine (A) to guanine (G) polymorphism at position -670 in the Fas gene (TNFRSF6) results in decreased Fas synthesis. The association between this polymorphism and pre-eclampsia in Hungarian women was investigated. In a case-control study, buccal swabs from 38 pregnant women with pre-eclampsia and 89 normotensive controls were analysed for the TNFRSF6-670 polymorphism. Investigators were blinded to clinical outcomes. Maternal homozygosity for the TNFRSF6-670*A occurred in 33 (37.1%) normotensive pregnant women as compared to only 5 (16.1%) of 31 pre-eclamptic pregnant women who delivered at

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalMolecular Human Reproduction
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Pre-Eclampsia
Pregnant Women
Growth
Mothers
Genes
Cheek
Guanine
Adenine
Case-Control Studies
Research Personnel
Lymphocytes
Apoptosis
Pregnancy

Keywords

  • Fas
  • Genetic polymorphism
  • Intrauterine growth restriction
  • Pre-eclampsia
  • TNFRSF6

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Genetics
  • Developmental Biology
  • Embryology
  • Cell Biology

Cite this

An A > G polymorphism at position - 670 in the Fas (TNFRSF6) gene in pregnant women with pre-eclampsia and intrauterine growth restriction. / Sziller, I.; Nguyen, Daniel; Halmos, Amrita; Hupuczi, P.; Papp, Z.; Witkin, Steven S.

In: Molecular Human Reproduction, Vol. 11, No. 3, 03.2005, p. 207-210.

Research output: Contribution to journalArticle

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