Amplification of hormone receptors by neonatal oxytocin and vasopressin treatment

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Newborn rats were treated once with 2 U of vasopressin (VP) or oxytocin, respectively. At the age of 2 mth and 1 yr, respectively, the reactivity of isolated aortic strips to vasopressin and noradrenaline was tested. In young adult animals vasopressin pretreatment enhanced whilst oxytocin pretreatment decreased the responsiveness of aortic strips to VO. In elder specimens both types of pretreatment resulted in an increased late sensitivity to VP. The norepinephrine-sensitivity was higher in the young adults pretreated with oxytocin, whilst in the elder ones vasopressin-retreatment gave the same late effect. It could be established that the hormone excess produced in the neonatal age led to the 'amplification' of hormone receptors and this alteration proved to be permanent. A compound which is similar to but not identical with the hormone - in the authors' case, oxytocin - would elicit an alteration of a less unidirectional and permanent type; late sensitivity changes in both directions may occur.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalHormone and Metabolic Research
Volume12
Issue number1
Publication statusPublished - 1980

Fingerprint

Oxytocin Receptors
Vasopressin Receptors
Oxytocin
Vasopressins
Amplification
Hormones
Young Adult
Norepinephrine
Therapeutics
Retreatment
Rats
Animals

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Amplification of hormone receptors by neonatal oxytocin and vasopressin treatment. / Csaba, G.; Rónai, A.; László, V.; Darvas, Z.; Berzétei, I.

In: Hormone and Metabolic Research, Vol. 12, No. 1, 1980, p. 28-31.

Research output: Contribution to journalArticle

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