Amphiphilic networks IV. Synthesis and characterization of, and drug release from poly(2-hydroxyethyl methacrylate)-polyisobutylene

Bela Ivan, Joseph P. Kennedy, Paul W. Mackey

Research output: Contribution to journalConference article

33 Citations (Scopus)

Abstract

Amphiphilic networks comprising poly(2-hydroxyethyl methacrylate) (PHEMA) and polyisobutylene (PIB) segments have been synthesized by radical copolymerization of 2-trimethylsiloxyethyl methacrylate with methacrylate-telechelic PIB (MA-PIB-MA) followed by acid catalyzed deprotection of the trimethylsilyl groups. Optimum synthetic conditions for networks of satisfactory properties have been developed and a series of PHEMA-ℓ-PIB networks has been demonstrated by swelling in both n-heptane and in water. Drug delivery system have been prepared by loading the networks with theophylline. Release studies indicate sustained release with anomalous diffusion kinetics.

Original languageEnglish
Pages (from-to)217-218
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume31
Issue number2
Publication statusPublished - Aug 1 1990
EventPapers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA
Duration: Aug 26 1990Aug 31 1990

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ASJC Scopus subject areas

  • Materials Science(all)
  • Polymers and Plastics
  • Engineering(all)

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