Amphiphilic networks IV. Synthesis and characterization of, and drug release from poly(2-hydroxyethyl methacrylate)-polyisobutylene

B. Iván, Joseph P. Kennedy, Paul W. Mackey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

33 Citations (Scopus)

Abstract

Amphiphilic networks comprising poly(2-hydroxyethyl methacrylate) (PHEMA) and polyisobutylene (PIB) segments have been synthesized by radical copolymerization of 2-trimethylsiloxyethyl methacrylate with methacrylate-telechelic PIB (MA-PIB-MA) followed by acid catalyzed deprotection of the trimethylsilyl groups. Optimum synthetic conditions for networks of satisfactory properties have been developed and a series of PHEMA-ℓ-PIB networks has been demonstrated by swelling in both n-heptane and in water. Drug delivery system have been prepared by loading the networks with theophylline. Release studies indicate sustained release with anomalous diffusion kinetics.

Original languageEnglish
Title of host publicationAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
PublisherPubl by ACS
Pages217-218
Number of pages2
Volume31
Edition2
Publication statusPublished - Aug 1990
EventPapers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA
Duration: Aug 26 1990Aug 31 1990

Other

OtherPapers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry
CityWashington, DC, USA
Period8/26/908/31/90

Fingerprint

Heptane
Copolymerization
Swelling
Kinetics
Methacrylates
Acids
Pharmaceutical Preparations
Water
Theophylline
Drug Delivery Systems
polyisobutylene
hydroxyethyl methacrylate

ASJC Scopus subject areas

  • Materials Science(all)
  • Polymers and Plastics
  • Engineering(all)

Cite this

Iván, B., Kennedy, J. P., & Mackey, P. W. (1990). Amphiphilic networks IV. Synthesis and characterization of, and drug release from poly(2-hydroxyethyl methacrylate)-polyisobutylene. In American Chemical Society, Polymer Preprints, Division of Polymer Chemistry (2 ed., Vol. 31, pp. 217-218). Publ by ACS.

Amphiphilic networks IV. Synthesis and characterization of, and drug release from poly(2-hydroxyethyl methacrylate)-polyisobutylene. / Iván, B.; Kennedy, Joseph P.; Mackey, Paul W.

American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. Vol. 31 2. ed. Publ by ACS, 1990. p. 217-218.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Iván, B, Kennedy, JP & Mackey, PW 1990, Amphiphilic networks IV. Synthesis and characterization of, and drug release from poly(2-hydroxyethyl methacrylate)-polyisobutylene. in American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 2 edn, vol. 31, Publ by ACS, pp. 217-218, Papers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry, Washington, DC, USA, 8/26/90.
Iván B, Kennedy JP, Mackey PW. Amphiphilic networks IV. Synthesis and characterization of, and drug release from poly(2-hydroxyethyl methacrylate)-polyisobutylene. In American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 2 ed. Vol. 31. Publ by ACS. 1990. p. 217-218
Iván, B. ; Kennedy, Joseph P. ; Mackey, Paul W. / Amphiphilic networks IV. Synthesis and characterization of, and drug release from poly(2-hydroxyethyl methacrylate)-polyisobutylene. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. Vol. 31 2. ed. Publ by ACS, 1990. pp. 217-218
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