AMPA amd NMDA receptors: Similarities and differences in their synaptic distribution

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Recent technical developments, including antigen-retrieval and electron microscopic immunogold methods, are making it possible to determine some of the basic principles governing the subcellular distribution of ionotropic glutamate receptors. Distinct AMPA and NMDA receptor subtypes are selectively targeted to functionally different synapses of a single cell, resulting in an input-selective fine-tuning and regulation of the postsynaptic responses. The amount, density and variability of AMPA receptors at a given glutamatergic synapse is governed by both pre- and postsynaptic factors, resulting in functionally distinct glutamatergic connections that display characteristic patterns of receptor expression.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalCurrent Opinion in Neurobiology
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 1 2000

ASJC Scopus subject areas

  • Neuroscience(all)

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