Amorphisation of nifluminic acid with polyvinylpyrrolidone prepared solid dispersion to reach rapid drug release

Rita Ambrus, Z. Aigner, Codruţa Şoica, Camelia Peev, P. Szabó-Révész

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This paper describes the enhancement of dissolution rate of nifluminic acid by spray dry process, as a solid dispersion method using polyvinylpyrrolidone (PVP C-15) as a water soluble polymer. Using solid dispersions as a well-known principle on an industrial scale, it has to be combined with low-cost and repetable manufacturing method. Therefore, the aim of the authors was the amorphisation of the drug applying another type of PVP and another sample-preparation method as earlier. The products were characterized by means of solubility and dissolution from simulated media. The wettability properties of the pure ingredient and its products were determined, with registration of their contact angles. The drug-polymer interaction in the solid state was investigated by using differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. The results suggested that the drug is found in the amorphous state in the solid dispersion and, using this method, it is possible to reach rapid drug release.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalRevista de Chimie
Volume58
Issue number2
Publication statusPublished - Feb 2007

Fingerprint

Povidone
Amorphization
Acids
Pharmaceutical Preparations
Polymers
Dissolution
Dispersions
X ray powder diffraction
Contact angle
Fourier transform infrared spectroscopy
Wetting
Differential scanning calorimetry
Solubility
Water
Costs

Keywords

  • Amorphisation
  • Nifluminic acid
  • Polyvinylpyrrolidone
  • Solid dispersion
  • Thermoanalytical investigations

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Amorphisation of nifluminic acid with polyvinylpyrrolidone prepared solid dispersion to reach rapid drug release. / Ambrus, Rita; Aigner, Z.; Şoica, Codruţa; Peev, Camelia; Szabó-Révész, P.

In: Revista de Chimie, Vol. 58, No. 2, 02.2007, p. 206-209.

Research output: Contribution to journalArticle

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