Amniotic membrane and the controlled drug release

Miklós D. Resch, László Marsovszky, Erzsébet Csányi, Mária Budai Szűcs, János Németh

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

In this chapter we give an overview on the factors affecting drug permeability in the normal eye, and demonstrate the effect of amniotic membrane on the ocular surface on drug release. Furthermore we focus mainly on topical ocular drug administration with regards to ocular surface and amniotic membrane. Amniotic membrane can have various effects on drug permeability and can significantly alter bioavailability of the drugs used. Beyond several biochemical, biological and biophysical benefits of amniotic membrane transplantation, amniotic membrane servesa layer with a more stable drug concentration on the ocular surface. Amniotic membrane has dual effect on drug penetration. First it acts as a barrier against drug penetration, and it has also a drug release activity.

Original languageEnglish
Title of host publicationAmniotic Membrane
Subtitle of host publicationOrigin Characterization and Medical Applications
PublisherSpringer Netherlands
Pages177-192
Number of pages16
ISBN (Electronic)9789401799751
ISBN (Print)9789401799744
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Amniotic membrane
  • Drug penetration
  • Ocular surface
  • Permeability
  • Pharmacology

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Resch, M. D., Marsovszky, L., Csányi, E., Szűcs, M. B., & Németh, J. (2015). Amniotic membrane and the controlled drug release. In Amniotic Membrane: Origin Characterization and Medical Applications (pp. 177-192). Springer Netherlands. https://doi.org/10.1007/978-94-017-9975-1_11