The study investigated the association between gestational diabetes and amniotic fluid insulin concentrations determined in the second trimester. Insulin concentrations in the amniotic fluid samples of 274 pregnant women were assessed by the authors, obtained by amniocentesis for genetic reasons, between the 16th and 23rd gestational weeks. 11 cases were excluded from the investigation on the grounds of genetic and chromosomal disorders, miscarriage and blood stained amniotic fluid samples. An oral glucose tolerance test (OGTT) using the WHO's recommendation (75g) was carried out in order to diagnose gestational diabetes mellitus. The mean value±SD of the amniotic fluids' insulin concentration was 1,82±0,84 μU/ml. Pathological amniotic fluid insulin level (>mean value+2SD) was seen with the incidence of 12/263 (4,56%). Positive OGTT was found in 25 pregnant women, among them in 5 cases it could be associated with a pathological amniotic fluid insulin concentration. The correlation between the abnormal OGTT values and the pathological amniotic fluid insulin levels (5/12, 42%) was found to be significant as compared to the normal amniotic insulin levels (20/251, 8%) (p<0,001, RR:5,23, 95% CI 2,37-11,53). The authors' conclude that determination of the amniotic fluid insulin levels during the second trimester may call attention early to the maternal carbohydrate metabolic derangement, however it should not be used as a screening method for predicting the presence of gestational diabetes.
|Translated title of the contribution||Amniotic fluid insulin concentrations in pregnant women during the second trimester related to gestational diabetes|
|Number of pages||5|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jun 16 2006|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology