Aminothiazoles and aminothiadiazoles as nucleophiles in aminocarbonylation of iodobenzene derivatives

Máté Gergely, L. Kollár

Research output: Contribution to journalArticle

Abstract

Various 2-, 3- and 4-substituted iodobenzenes were aminocarbonylated using aminothiazole and aminothiadiazole derivatives in palladium-catalysed reaction. The reaction is chemospecific toward the corresponding carboxamides. Consequently, the application of the above N-nucleophiles provided the N-1,3-thiazol-2-yl- and N-1,3,4-thiadiazol-2-ylcarboxamides in moderate to high yields. Due to the facile work-up of the reaction mixture isolated yields of 90% or higher were obtained in most cases.

Original languageEnglish
Pages (from-to)2030-2040
Number of pages11
JournalTetrahedron
Volume74
Issue number16
DOIs
Publication statusPublished - Apr 19 2018

Fingerprint

2-amino-1,3,4-thiadiazole
Iodobenzenes
Nucleophiles
Palladium
Derivatives
iodobenzene

Keywords

  • Carbon monoxide
  • Carbonylation
  • Carboxamide
  • Iodoarene
  • Palladium
  • Thiazole

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Aminothiazoles and aminothiadiazoles as nucleophiles in aminocarbonylation of iodobenzene derivatives. / Gergely, Máté; Kollár, L.

In: Tetrahedron, Vol. 74, No. 16, 19.04.2018, p. 2030-2040.

Research output: Contribution to journalArticle

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