Aminosäurestoffwechsel bei experimenteller Pankreatitis an der Ratte

Translated title of the contribution: Amino acid metabolism of acute pancreatitis in an experimental rat model

G. Zöch, E. Roth, N. Hölbling, J. Karner, J. Funovics, K. Cervenka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Previous metabolic studies in clinical acute pancreatitis revealed drastic changes of the amino acid (AA) metabolism as the result of a catabolic situation of the patients. In this study the AA metabolism in two experimental rat models was investigated. Acute pancreatitis was produced either with ethionine or with phospholipase plus bile. Total plasma AA concentrations (vena cava inferior) were significantly increased in both groups of rats as compared to normal rats (P<0.001). The concentrations of glutamate, glycine, alanine, 3-methylhistidine (P<0.05), of valine, isoleucine, leucine, phenylalanine (P<0.001), and also of tyrosine (P<0.01) were significantly increased in the phospholipase model, whereas those of threonine, serine, glutamine, methionine, 3-methylhistidine (P<0.05), of valine, isoleucine, leucine, phenylalanine (P<0.01), and also of glycine and alanine (P<0.001) were increased in ethionine-produced pancreatitis. These results reveal divergent results of the AA metabolism in experimental and clinical pancreatitis. A possible explanation for the difference may be the prolonged catabolic state of the patients at the time of evaluation resulting in decreased protein and AA pools. In contrast, in the rat models the early phase of acute pancreatitis not yet influenced by malnutrition may lead to an increased mobilization of muscle AA expressed in high levels of plasma amino acids.

Translated title of the contributionAmino acid metabolism of acute pancreatitis in an experimental rat model
Original languageGerman
Pages (from-to)231-238
Number of pages8
JournalResearch In Experimental Medicine
Volume181
Issue number3
DOIs
Publication statusPublished - Oct 1 1982

Keywords

  • Acute pancreatitis
  • Amino acid metabolism
  • Protein catabolism

ASJC Scopus subject areas

  • Medicine(all)

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