Ambulatory arterial stiffness in chronic kidney disease

A methodological review

Andrea László, G. Reusz, János Nemcsik

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cardiovascular mortality is the leading cause of death in chronic kidney disease (CKD) and end-stage renal disease (ESRD). This can be explained in part by an increased and progressive calcification of the medial layer of the large arteries leading to arterial stiffening. The prognostic value of measurements of arterial stiffness, especially pulse wave velocity (PWV), in the general population and in CKD and ESRD patients is high, and is above that of traditional risk factors with respect to cardiovascular outcome. In recent years, as an alternative to office measurements, methods for monitoring ambulatory arterial stiffness have been developed. The ambulatory arterial stiffness index (AASI) allows derivation of a parameter from ambulatory blood pressure measurements; however, doubts have emerged about the usefulness of this parameter. Recently, new oscillometric methodologies using simple brachial cuffs, such as Mobil-O-Graph, Vasotens or Arteriograph 24, have been introduced. They measure parameters of 24-h arterial stiffness including PWV, augmentation index and central blood pressure. This enables study of the 24-h variability of these parameters, which will hopefully lead to better cardiovascular risk stratification and improved cardiovascular outcomes of patients. Our review summarizes the present data and future directions of AASI and the methods for monitoring oscillometric 24-h stiffness in different patient populations and especially in CKD.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalHypertension Research
Volume39
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Vascular Stiffness
Chronic Renal Insufficiency
Pulse Wave Analysis
Chronic Kidney Failure
Blood Pressure
Ambulatory Monitoring
Population
Cause of Death
Arm
Arteries
Mortality

Keywords

  • ambulatory arterial stiffness index
  • ambulatory arterial stiffness monitoring
  • ambulatory blood pressure monitoring
  • chronic kidney disease

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Ambulatory arterial stiffness in chronic kidney disease : A methodological review. / László, Andrea; Reusz, G.; Nemcsik, János.

In: Hypertension Research, Vol. 39, No. 4, 01.04.2016, p. 192-198.

Research output: Contribution to journalArticle

László, Andrea ; Reusz, G. ; Nemcsik, János. / Ambulatory arterial stiffness in chronic kidney disease : A methodological review. In: Hypertension Research. 2016 ; Vol. 39, No. 4. pp. 192-198.
@article{fe75ca6a32f047579cd0220f05158bb2,
title = "Ambulatory arterial stiffness in chronic kidney disease: A methodological review",
abstract = "Cardiovascular mortality is the leading cause of death in chronic kidney disease (CKD) and end-stage renal disease (ESRD). This can be explained in part by an increased and progressive calcification of the medial layer of the large arteries leading to arterial stiffening. The prognostic value of measurements of arterial stiffness, especially pulse wave velocity (PWV), in the general population and in CKD and ESRD patients is high, and is above that of traditional risk factors with respect to cardiovascular outcome. In recent years, as an alternative to office measurements, methods for monitoring ambulatory arterial stiffness have been developed. The ambulatory arterial stiffness index (AASI) allows derivation of a parameter from ambulatory blood pressure measurements; however, doubts have emerged about the usefulness of this parameter. Recently, new oscillometric methodologies using simple brachial cuffs, such as Mobil-O-Graph, Vasotens or Arteriograph 24, have been introduced. They measure parameters of 24-h arterial stiffness including PWV, augmentation index and central blood pressure. This enables study of the 24-h variability of these parameters, which will hopefully lead to better cardiovascular risk stratification and improved cardiovascular outcomes of patients. Our review summarizes the present data and future directions of AASI and the methods for monitoring oscillometric 24-h stiffness in different patient populations and especially in CKD.",
keywords = "ambulatory arterial stiffness index, ambulatory arterial stiffness monitoring, ambulatory blood pressure monitoring, chronic kidney disease",
author = "Andrea L{\'a}szl{\'o} and G. Reusz and J{\'a}nos Nemcsik",
year = "2016",
month = "4",
day = "1",
doi = "10.1038/hr.2015.137",
language = "English",
volume = "39",
pages = "192--198",
journal = "Hypertension Research",
issn = "0916-9636",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Ambulatory arterial stiffness in chronic kidney disease

T2 - A methodological review

AU - László, Andrea

AU - Reusz, G.

AU - Nemcsik, János

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Cardiovascular mortality is the leading cause of death in chronic kidney disease (CKD) and end-stage renal disease (ESRD). This can be explained in part by an increased and progressive calcification of the medial layer of the large arteries leading to arterial stiffening. The prognostic value of measurements of arterial stiffness, especially pulse wave velocity (PWV), in the general population and in CKD and ESRD patients is high, and is above that of traditional risk factors with respect to cardiovascular outcome. In recent years, as an alternative to office measurements, methods for monitoring ambulatory arterial stiffness have been developed. The ambulatory arterial stiffness index (AASI) allows derivation of a parameter from ambulatory blood pressure measurements; however, doubts have emerged about the usefulness of this parameter. Recently, new oscillometric methodologies using simple brachial cuffs, such as Mobil-O-Graph, Vasotens or Arteriograph 24, have been introduced. They measure parameters of 24-h arterial stiffness including PWV, augmentation index and central blood pressure. This enables study of the 24-h variability of these parameters, which will hopefully lead to better cardiovascular risk stratification and improved cardiovascular outcomes of patients. Our review summarizes the present data and future directions of AASI and the methods for monitoring oscillometric 24-h stiffness in different patient populations and especially in CKD.

AB - Cardiovascular mortality is the leading cause of death in chronic kidney disease (CKD) and end-stage renal disease (ESRD). This can be explained in part by an increased and progressive calcification of the medial layer of the large arteries leading to arterial stiffening. The prognostic value of measurements of arterial stiffness, especially pulse wave velocity (PWV), in the general population and in CKD and ESRD patients is high, and is above that of traditional risk factors with respect to cardiovascular outcome. In recent years, as an alternative to office measurements, methods for monitoring ambulatory arterial stiffness have been developed. The ambulatory arterial stiffness index (AASI) allows derivation of a parameter from ambulatory blood pressure measurements; however, doubts have emerged about the usefulness of this parameter. Recently, new oscillometric methodologies using simple brachial cuffs, such as Mobil-O-Graph, Vasotens or Arteriograph 24, have been introduced. They measure parameters of 24-h arterial stiffness including PWV, augmentation index and central blood pressure. This enables study of the 24-h variability of these parameters, which will hopefully lead to better cardiovascular risk stratification and improved cardiovascular outcomes of patients. Our review summarizes the present data and future directions of AASI and the methods for monitoring oscillometric 24-h stiffness in different patient populations and especially in CKD.

KW - ambulatory arterial stiffness index

KW - ambulatory arterial stiffness monitoring

KW - ambulatory blood pressure monitoring

KW - chronic kidney disease

UR - http://www.scopus.com/inward/record.url?scp=84962672245&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962672245&partnerID=8YFLogxK

U2 - 10.1038/hr.2015.137

DO - 10.1038/hr.2015.137

M3 - Article

VL - 39

SP - 192

EP - 198

JO - Hypertension Research

JF - Hypertension Research

SN - 0916-9636

IS - 4

ER -