Ambient air pollution and low birthweight

A European cohort study (ESCAPE)

Marie Pedersen, Lise Giorgis-Allemand, Claire Bernard, Inmaculada Aguilera, Anne Marie Nybo Andersen, Ferran Ballester, Rob M J Beelen, Leda Chatzi, Marta Cirach, Asta Danileviciute, Audrius Dedele, Manon van Eijsden, Marisa Estarlich, Ana Fernández-Somoano, Mariana F. Fernández, Francesco Forastiere, Ulrike Gehring, Regina Grazuleviciene, Olena Gruzieva, Barbara Heude & 32 others Gerard Hoek, Kees de Hoogh, Edith H. van den Hooven, Siri E. Håberg, Vincent W V Jaddoe, Claudia Klümper, Michal Korek, Ursula Krämer, Aitana Lerchundi, Johanna Lepeule, Per Nafstad, Wenche Nystad, Evridiki Patelarou, Daniela Porta, Dirkje Postma, Ole Raaschou-Nielsen, P. Rudnai, Jordi Sunyer, Euripides Stephanou, Mette Sørensen, Elisabeth Thiering, Derek Tuffnell, Mihály J. Varró, Tanja G M Vrijkotte, Alet Wijga, Michael Wilhelm, John Wright, Mark J. Nieuwenhuijsen, Göran Pershagen, Bert Brunekreef, Manolis Kogevinas, Rémy Slama

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

Background: Ambient air pollution has been associated with restricted fetal growth, which is linked with adverse respiratory health in childhood. We assessed the effect of maternal exposure to low concentrations of ambient air pollution on birthweight. Methods: We pooled data from 14 population-based mother-child cohort studies in 12 European countries. Overall, the study population included 74178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight 25), less than 10 μm (PM10), and between 25 μm and 10 μm during pregnancy were estimated at maternal home addresses with temporally adjusted land-use regression models, as was PM25 absorbance and concentrations of nitrogen dioxide (NO2) and nitrogen oxides. We also investigated traffic density on the nearest road and total traffic load. We calculated pooled effect estimates with random-effects models. Findings: A 5 μg/m3 increase in concentration of PM25 during pregnancy was associated with an increased risk of low birthweight at term (adjusted odds ratio [OR] 118, 95% CI 106-133). An increased risk was also recorded for pregnancy concentrations lower than the present European Union annual PM25 limit of 25 μg/m3 (OR for 5 μg/m3 increase in participants exposed to concentrations of less than 20 μg/m3 141, 95% CI 120-165). PM10 (OR for 10 μg/m3 increase 116, 95% CI 100-135), NO2 (OR for 10 μg/m3 increase 109, 100-119), and traffic density on nearest street (OR for increase of 5000 vehicles per day 106, 101-111) were also associated with increased risk of low birthweight at term. The population attributable risk estimated for a reduction in PM25 concentration to 10 μg/m3 during pregnancy corresponded to a decrease of 22% (95% CI 8-33%) in cases of low birthweight at term. Interpretation: Exposure to ambient air pollutants and traffic during pregnancy is associated with restricted fetal growth. A substantial proportion of cases of low birthweight at term could be prevented in Europe if urban air pollution was reduced. Funding: The European Union.

Original languageEnglish
Pages (from-to)695-704
Number of pages10
JournalThe Lancet Respiratory Medicine
Volume1
Issue number9
DOIs
Publication statusPublished - Nov 2013

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Air Pollution
Cohort Studies
Odds Ratio
Pregnancy
Nitrogen Dioxide
European Union
Fetal Development
Mothers
Population
Maternal Exposure
Air Pollutants
Gestational Age
Weights and Measures
Health

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Pedersen, M., Giorgis-Allemand, L., Bernard, C., Aguilera, I., Andersen, A. M. N., Ballester, F., ... Slama, R. (2013). Ambient air pollution and low birthweight: A European cohort study (ESCAPE). The Lancet Respiratory Medicine, 1(9), 695-704. https://doi.org/10.1016/S2213-2600(13)70192-9

Ambient air pollution and low birthweight : A European cohort study (ESCAPE). / Pedersen, Marie; Giorgis-Allemand, Lise; Bernard, Claire; Aguilera, Inmaculada; Andersen, Anne Marie Nybo; Ballester, Ferran; Beelen, Rob M J; Chatzi, Leda; Cirach, Marta; Danileviciute, Asta; Dedele, Audrius; Eijsden, Manon van; Estarlich, Marisa; Fernández-Somoano, Ana; Fernández, Mariana F.; Forastiere, Francesco; Gehring, Ulrike; Grazuleviciene, Regina; Gruzieva, Olena; Heude, Barbara; Hoek, Gerard; Hoogh, Kees de; van den Hooven, Edith H.; Håberg, Siri E.; Jaddoe, Vincent W V; Klümper, Claudia; Korek, Michal; Krämer, Ursula; Lerchundi, Aitana; Lepeule, Johanna; Nafstad, Per; Nystad, Wenche; Patelarou, Evridiki; Porta, Daniela; Postma, Dirkje; Raaschou-Nielsen, Ole; Rudnai, P.; Sunyer, Jordi; Stephanou, Euripides; Sørensen, Mette; Thiering, Elisabeth; Tuffnell, Derek; Varró, Mihály J.; Vrijkotte, Tanja G M; Wijga, Alet; Wilhelm, Michael; Wright, John; Nieuwenhuijsen, Mark J.; Pershagen, Göran; Brunekreef, Bert; Kogevinas, Manolis; Slama, Rémy.

In: The Lancet Respiratory Medicine, Vol. 1, No. 9, 11.2013, p. 695-704.

Research output: Contribution to journalArticle

Pedersen, M, Giorgis-Allemand, L, Bernard, C, Aguilera, I, Andersen, AMN, Ballester, F, Beelen, RMJ, Chatzi, L, Cirach, M, Danileviciute, A, Dedele, A, Eijsden, MV, Estarlich, M, Fernández-Somoano, A, Fernández, MF, Forastiere, F, Gehring, U, Grazuleviciene, R, Gruzieva, O, Heude, B, Hoek, G, Hoogh, KD, van den Hooven, EH, Håberg, SE, Jaddoe, VWV, Klümper, C, Korek, M, Krämer, U, Lerchundi, A, Lepeule, J, Nafstad, P, Nystad, W, Patelarou, E, Porta, D, Postma, D, Raaschou-Nielsen, O, Rudnai, P, Sunyer, J, Stephanou, E, Sørensen, M, Thiering, E, Tuffnell, D, Varró, MJ, Vrijkotte, TGM, Wijga, A, Wilhelm, M, Wright, J, Nieuwenhuijsen, MJ, Pershagen, G, Brunekreef, B, Kogevinas, M & Slama, R 2013, 'Ambient air pollution and low birthweight: A European cohort study (ESCAPE)', The Lancet Respiratory Medicine, vol. 1, no. 9, pp. 695-704. https://doi.org/10.1016/S2213-2600(13)70192-9
Pedersen M, Giorgis-Allemand L, Bernard C, Aguilera I, Andersen AMN, Ballester F et al. Ambient air pollution and low birthweight: A European cohort study (ESCAPE). The Lancet Respiratory Medicine. 2013 Nov;1(9):695-704. https://doi.org/10.1016/S2213-2600(13)70192-9
Pedersen, Marie ; Giorgis-Allemand, Lise ; Bernard, Claire ; Aguilera, Inmaculada ; Andersen, Anne Marie Nybo ; Ballester, Ferran ; Beelen, Rob M J ; Chatzi, Leda ; Cirach, Marta ; Danileviciute, Asta ; Dedele, Audrius ; Eijsden, Manon van ; Estarlich, Marisa ; Fernández-Somoano, Ana ; Fernández, Mariana F. ; Forastiere, Francesco ; Gehring, Ulrike ; Grazuleviciene, Regina ; Gruzieva, Olena ; Heude, Barbara ; Hoek, Gerard ; Hoogh, Kees de ; van den Hooven, Edith H. ; Håberg, Siri E. ; Jaddoe, Vincent W V ; Klümper, Claudia ; Korek, Michal ; Krämer, Ursula ; Lerchundi, Aitana ; Lepeule, Johanna ; Nafstad, Per ; Nystad, Wenche ; Patelarou, Evridiki ; Porta, Daniela ; Postma, Dirkje ; Raaschou-Nielsen, Ole ; Rudnai, P. ; Sunyer, Jordi ; Stephanou, Euripides ; Sørensen, Mette ; Thiering, Elisabeth ; Tuffnell, Derek ; Varró, Mihály J. ; Vrijkotte, Tanja G M ; Wijga, Alet ; Wilhelm, Michael ; Wright, John ; Nieuwenhuijsen, Mark J. ; Pershagen, Göran ; Brunekreef, Bert ; Kogevinas, Manolis ; Slama, Rémy. / Ambient air pollution and low birthweight : A European cohort study (ESCAPE). In: The Lancet Respiratory Medicine. 2013 ; Vol. 1, No. 9. pp. 695-704.
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abstract = "Background: Ambient air pollution has been associated with restricted fetal growth, which is linked with adverse respiratory health in childhood. We assessed the effect of maternal exposure to low concentrations of ambient air pollution on birthweight. Methods: We pooled data from 14 population-based mother-child cohort studies in 12 European countries. Overall, the study population included 74178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight 25), less than 10 μm (PM10), and between 25 μm and 10 μm during pregnancy were estimated at maternal home addresses with temporally adjusted land-use regression models, as was PM25 absorbance and concentrations of nitrogen dioxide (NO2) and nitrogen oxides. We also investigated traffic density on the nearest road and total traffic load. We calculated pooled effect estimates with random-effects models. Findings: A 5 μg/m3 increase in concentration of PM25 during pregnancy was associated with an increased risk of low birthweight at term (adjusted odds ratio [OR] 118, 95{\%} CI 106-133). An increased risk was also recorded for pregnancy concentrations lower than the present European Union annual PM25 limit of 25 μg/m3 (OR for 5 μg/m3 increase in participants exposed to concentrations of less than 20 μg/m3 141, 95{\%} CI 120-165). PM10 (OR for 10 μg/m3 increase 116, 95{\%} CI 100-135), NO2 (OR for 10 μg/m3 increase 109, 100-119), and traffic density on nearest street (OR for increase of 5000 vehicles per day 106, 101-111) were also associated with increased risk of low birthweight at term. The population attributable risk estimated for a reduction in PM25 concentration to 10 μg/m3 during pregnancy corresponded to a decrease of 22{\%} (95{\%} CI 8-33{\%}) in cases of low birthweight at term. Interpretation: Exposure to ambient air pollutants and traffic during pregnancy is associated with restricted fetal growth. A substantial proportion of cases of low birthweight at term could be prevented in Europe if urban air pollution was reduced. Funding: The European Union.",
author = "Marie Pedersen and Lise Giorgis-Allemand and Claire Bernard and Inmaculada Aguilera and Andersen, {Anne Marie Nybo} and Ferran Ballester and Beelen, {Rob M J} and Leda Chatzi and Marta Cirach and Asta Danileviciute and Audrius Dedele and Eijsden, {Manon van} and Marisa Estarlich and Ana Fern{\'a}ndez-Somoano and Fern{\'a}ndez, {Mariana F.} and Francesco Forastiere and Ulrike Gehring and Regina Grazuleviciene and Olena Gruzieva and Barbara Heude and Gerard Hoek and Hoogh, {Kees de} and {van den Hooven}, {Edith H.} and H{\aa}berg, {Siri E.} and Jaddoe, {Vincent W V} and Claudia Kl{\"u}mper and Michal Korek and Ursula Kr{\"a}mer and Aitana Lerchundi and Johanna Lepeule and Per Nafstad and Wenche Nystad and Evridiki Patelarou and Daniela Porta and Dirkje Postma and Ole Raaschou-Nielsen and P. Rudnai and Jordi Sunyer and Euripides Stephanou and Mette S{\o}rensen and Elisabeth Thiering and Derek Tuffnell and Varr{\'o}, {Mih{\'a}ly J.} and Vrijkotte, {Tanja G M} and Alet Wijga and Michael Wilhelm and John Wright and Nieuwenhuijsen, {Mark J.} and G{\"o}ran Pershagen and Bert Brunekreef and Manolis Kogevinas and R{\'e}my Slama",
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doi = "10.1016/S2213-2600(13)70192-9",
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TY - JOUR

T1 - Ambient air pollution and low birthweight

T2 - A European cohort study (ESCAPE)

AU - Pedersen, Marie

AU - Giorgis-Allemand, Lise

AU - Bernard, Claire

AU - Aguilera, Inmaculada

AU - Andersen, Anne Marie Nybo

AU - Ballester, Ferran

AU - Beelen, Rob M J

AU - Chatzi, Leda

AU - Cirach, Marta

AU - Danileviciute, Asta

AU - Dedele, Audrius

AU - Eijsden, Manon van

AU - Estarlich, Marisa

AU - Fernández-Somoano, Ana

AU - Fernández, Mariana F.

AU - Forastiere, Francesco

AU - Gehring, Ulrike

AU - Grazuleviciene, Regina

AU - Gruzieva, Olena

AU - Heude, Barbara

AU - Hoek, Gerard

AU - Hoogh, Kees de

AU - van den Hooven, Edith H.

AU - Håberg, Siri E.

AU - Jaddoe, Vincent W V

AU - Klümper, Claudia

AU - Korek, Michal

AU - Krämer, Ursula

AU - Lerchundi, Aitana

AU - Lepeule, Johanna

AU - Nafstad, Per

AU - Nystad, Wenche

AU - Patelarou, Evridiki

AU - Porta, Daniela

AU - Postma, Dirkje

AU - Raaschou-Nielsen, Ole

AU - Rudnai, P.

AU - Sunyer, Jordi

AU - Stephanou, Euripides

AU - Sørensen, Mette

AU - Thiering, Elisabeth

AU - Tuffnell, Derek

AU - Varró, Mihály J.

AU - Vrijkotte, Tanja G M

AU - Wijga, Alet

AU - Wilhelm, Michael

AU - Wright, John

AU - Nieuwenhuijsen, Mark J.

AU - Pershagen, Göran

AU - Brunekreef, Bert

AU - Kogevinas, Manolis

AU - Slama, Rémy

PY - 2013/11

Y1 - 2013/11

N2 - Background: Ambient air pollution has been associated with restricted fetal growth, which is linked with adverse respiratory health in childhood. We assessed the effect of maternal exposure to low concentrations of ambient air pollution on birthweight. Methods: We pooled data from 14 population-based mother-child cohort studies in 12 European countries. Overall, the study population included 74178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight 25), less than 10 μm (PM10), and between 25 μm and 10 μm during pregnancy were estimated at maternal home addresses with temporally adjusted land-use regression models, as was PM25 absorbance and concentrations of nitrogen dioxide (NO2) and nitrogen oxides. We also investigated traffic density on the nearest road and total traffic load. We calculated pooled effect estimates with random-effects models. Findings: A 5 μg/m3 increase in concentration of PM25 during pregnancy was associated with an increased risk of low birthweight at term (adjusted odds ratio [OR] 118, 95% CI 106-133). An increased risk was also recorded for pregnancy concentrations lower than the present European Union annual PM25 limit of 25 μg/m3 (OR for 5 μg/m3 increase in participants exposed to concentrations of less than 20 μg/m3 141, 95% CI 120-165). PM10 (OR for 10 μg/m3 increase 116, 95% CI 100-135), NO2 (OR for 10 μg/m3 increase 109, 100-119), and traffic density on nearest street (OR for increase of 5000 vehicles per day 106, 101-111) were also associated with increased risk of low birthweight at term. The population attributable risk estimated for a reduction in PM25 concentration to 10 μg/m3 during pregnancy corresponded to a decrease of 22% (95% CI 8-33%) in cases of low birthweight at term. Interpretation: Exposure to ambient air pollutants and traffic during pregnancy is associated with restricted fetal growth. A substantial proportion of cases of low birthweight at term could be prevented in Europe if urban air pollution was reduced. Funding: The European Union.

AB - Background: Ambient air pollution has been associated with restricted fetal growth, which is linked with adverse respiratory health in childhood. We assessed the effect of maternal exposure to low concentrations of ambient air pollution on birthweight. Methods: We pooled data from 14 population-based mother-child cohort studies in 12 European countries. Overall, the study population included 74178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight 25), less than 10 μm (PM10), and between 25 μm and 10 μm during pregnancy were estimated at maternal home addresses with temporally adjusted land-use regression models, as was PM25 absorbance and concentrations of nitrogen dioxide (NO2) and nitrogen oxides. We also investigated traffic density on the nearest road and total traffic load. We calculated pooled effect estimates with random-effects models. Findings: A 5 μg/m3 increase in concentration of PM25 during pregnancy was associated with an increased risk of low birthweight at term (adjusted odds ratio [OR] 118, 95% CI 106-133). An increased risk was also recorded for pregnancy concentrations lower than the present European Union annual PM25 limit of 25 μg/m3 (OR for 5 μg/m3 increase in participants exposed to concentrations of less than 20 μg/m3 141, 95% CI 120-165). PM10 (OR for 10 μg/m3 increase 116, 95% CI 100-135), NO2 (OR for 10 μg/m3 increase 109, 100-119), and traffic density on nearest street (OR for increase of 5000 vehicles per day 106, 101-111) were also associated with increased risk of low birthweight at term. The population attributable risk estimated for a reduction in PM25 concentration to 10 μg/m3 during pregnancy corresponded to a decrease of 22% (95% CI 8-33%) in cases of low birthweight at term. Interpretation: Exposure to ambient air pollutants and traffic during pregnancy is associated with restricted fetal growth. A substantial proportion of cases of low birthweight at term could be prevented in Europe if urban air pollution was reduced. Funding: The European Union.

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