Alzheimer's lymphocytes are resistant to ultraviolet B-induced apoptosis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimer's disease (AD) subjects (n = 22) and aged-matched, non-demented controls (CNT) (n = 12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p < 0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm2). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation.

Original languageEnglish
Pages (from-to)831-834
Number of pages4
JournalNeurobiology of Aging
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 1 2006

    Fingerprint

Keywords

  • Alzheimer's disease
  • Apoptosis
  • Flow cytometry
  • T-lymphocytes
  • Ultraviolet B irradiation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this