Alzheimer's lymphocytes are resistant to ultraviolet B-induced apoptosis

Marianna Zana, A. Juhász, A. Rimanóczy, Annamária Bjelik, Eszter Baltás, I. Ocsovszki, K. Boda, B. Penke, A. Dobozy, L. Kemény, Z. Janka, J. Kálmán

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimer's disease (AD) subjects (n = 22) and aged-matched, non-demented controls (CNT) (n = 12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p <0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm2). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation.

Original languageEnglish
Pages (from-to)831-834
Number of pages4
JournalNeurobiology of Aging
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Lymphocytes
Apoptosis
Alzheimer Disease
Ultraviolet Rays
T-Lymphocytes
In Vitro Techniques

Keywords

  • Alzheimer's disease
  • Apoptosis
  • Flow cytometry
  • T-lymphocytes
  • Ultraviolet B irradiation

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Alzheimer's lymphocytes are resistant to ultraviolet B-induced apoptosis. / Zana, Marianna; Juhász, A.; Rimanóczy, A.; Bjelik, Annamária; Baltás, Eszter; Ocsovszki, I.; Boda, K.; Penke, B.; Dobozy, A.; Kemény, L.; Janka, Z.; Kálmán, J.

In: Neurobiology of Aging, Vol. 27, No. 6, 06.2006, p. 831-834.

Research output: Contribution to journalArticle

@article{4e0f654935f844c886276d0ef24a99f2,
title = "Alzheimer's lymphocytes are resistant to ultraviolet B-induced apoptosis",
abstract = "In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimer's disease (AD) subjects (n = 22) and aged-matched, non-demented controls (CNT) (n = 12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p <0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm2). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation.",
keywords = "Alzheimer's disease, Apoptosis, Flow cytometry, T-lymphocytes, Ultraviolet B irradiation",
author = "Marianna Zana and A. Juh{\'a}sz and A. Riman{\'o}czy and Annam{\'a}ria Bjelik and Eszter Balt{\'a}s and I. Ocsovszki and K. Boda and B. Penke and A. Dobozy and L. Kem{\'e}ny and Z. Janka and J. K{\'a}lm{\'a}n",
year = "2006",
month = "6",
doi = "10.1016/j.neurobiolaging.2005.04.007",
language = "English",
volume = "27",
pages = "831--834",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Alzheimer's lymphocytes are resistant to ultraviolet B-induced apoptosis

AU - Zana, Marianna

AU - Juhász, A.

AU - Rimanóczy, A.

AU - Bjelik, Annamária

AU - Baltás, Eszter

AU - Ocsovszki, I.

AU - Boda, K.

AU - Penke, B.

AU - Dobozy, A.

AU - Kemény, L.

AU - Janka, Z.

AU - Kálmán, J.

PY - 2006/6

Y1 - 2006/6

N2 - In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimer's disease (AD) subjects (n = 22) and aged-matched, non-demented controls (CNT) (n = 12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p <0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm2). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation.

AB - In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimer's disease (AD) subjects (n = 22) and aged-matched, non-demented controls (CNT) (n = 12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p <0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm2). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation.

KW - Alzheimer's disease

KW - Apoptosis

KW - Flow cytometry

KW - T-lymphocytes

KW - Ultraviolet B irradiation

UR - http://www.scopus.com/inward/record.url?scp=33646205953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646205953&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2005.04.007

DO - 10.1016/j.neurobiolaging.2005.04.007

M3 - Article

C2 - 15961188

AN - SCOPUS:33646205953

VL - 27

SP - 831

EP - 834

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 6

ER -