Alveolitis may persist during treatment that sufficiently controls muscle inflammation in myositis

A. Komócsi, G. Kumánovics, H. Zibotics, L. Czirják

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Eight patients with dermato- and polymyositis (DM/PM) and two further cases with sclerodermamyositis overlap syndrome were investigated. These patients showed signs of lung manifestation by noninvasive methods. Bronchoalveolar lavage (BAL) was performed to detect alveolitis. Four of the eight DM/PM patients showed elevated neutrophil counts. All of these and one additional case had increased lymphocyte counts. Five of the DM/PM patients showed higher total cell numbers than five healthy controls. One of the cases with scleroderma-myositis overlap syndrome also developed lymphocyte alveolitis. We conclude that signs of alveolitis are often present in patients with myositis, even though the myositis was adequately controlled by corticosteroid therapy and, in four cases, with corticosteroid plus azathioprine. The need for further follow-up studies to determine the effectiveness of intensified corticosteroid/cytostatic treatment in these patients is emphasised.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalRheumatology International
Volume20
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Myositis
Inflammation
Muscles
Dermatomyositis
Adrenal Cortex Hormones
Therapeutics
Azathioprine
Lymphocyte Count
Cytostatic Agents
Bronchoalveolar Lavage
Neutrophils
Cell Count
Lymphocytes
Lung

Keywords

  • Alveolitis
  • Bronchoalveolar lavage
  • Dermato-/polymyositis
  • Lung fibrosis
  • Sclerodermamyositis overlap syndrome

ASJC Scopus subject areas

  • Rheumatology

Cite this

Alveolitis may persist during treatment that sufficiently controls muscle inflammation in myositis. / Komócsi, A.; Kumánovics, G.; Zibotics, H.; Czirják, L.

In: Rheumatology International, Vol. 20, No. 3, 2001, p. 113-118.

Research output: Contribution to journalArticle

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