Aluminium(III) as a promoter of cellular oxidation

Paolo Zatta, Tamas Kiss, Mario Suwalsky, Guy Berthon

Research output: Contribution to journalReview article

129 Citations (Scopus)

Abstract

Aid has been known as a neurotoxic agent to experimental animals since the last century (Arch. Exp. Pharmacol. 40 (1897) 98). However, great interest arose in it bioinorganic chemistry as well biology when it was demonstrated to be the causative agent in pathologies related to the long-term dialysis treatment of uremic subjects with renal failure (Life Chem. 11 (1994) 197), and as a potential etiopathogenic cofactor for several neurodegenerative diseases. The inorganic biochemistry of aid is still largely to be discovered. In this review the pro-oxidative property of aid toward biological membrane will be presented and its implications in involvement in human pathology will be discussed in an interdisciplinary frame from the bioinorganic point of view.

Original languageEnglish
Pages (from-to)271-284
Number of pages14
JournalCoordination Chemistry Reviews
Volume228
Issue number2
DOIs
Publication statusPublished - Jun 3 2002

Keywords

  • Aluminium
  • Alzheimer's disease
  • Antioxidative enzyme
  • Free radicals
  • Lipid peroxidation
  • Metal ions
  • Neurodegeneration
  • Plasma membrane

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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