Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

Xianjin Cui, Salome Belo, Dirk Krüger, Yong Yan, Rafael T M de Rosales, Maite Jauregui-Osoro, Haitao Ye, Shi Su, Domokos Mathe, Noémi Kovács, I. Horváth, Mariann Semjeni, Kavitha Sunassee, Krisztian Szigeti, Mark A. Green, Philip J. Blower

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. Invivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu.

Original languageEnglish
Pages (from-to)5840-5846
Number of pages7
JournalBiomaterials
Volume35
Issue number22
DOIs
Publication statusPublished - 2014

Fingerprint

Aluminum Hydroxide
Hydrated alumina
Nanoparticles
Magnetic resonance imaging
Contrast Media
Imaging techniques
Diphosphonates
Fluorides
Hydrolysis
Molecular imaging
Molecular Imaging
Radioactivity
Hardness
manganese ferrite
Temperature
Water

Keywords

  • Aluminium hydroxide
  • Dual-modal
  • Magnetic nanoparticles
  • MR
  • PET

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics
  • Medicine(all)

Cite this

Cui, X., Belo, S., Krüger, D., Yan, Y., de Rosales, R. T. M., Jauregui-Osoro, M., ... Blower, P. J. (2014). Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging. Biomaterials, 35(22), 5840-5846. https://doi.org/10.1016/j.biomaterials.2014.04.004

Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging. / Cui, Xianjin; Belo, Salome; Krüger, Dirk; Yan, Yong; de Rosales, Rafael T M; Jauregui-Osoro, Maite; Ye, Haitao; Su, Shi; Mathe, Domokos; Kovács, Noémi; Horváth, I.; Semjeni, Mariann; Sunassee, Kavitha; Szigeti, Krisztian; Green, Mark A.; Blower, Philip J.

In: Biomaterials, Vol. 35, No. 22, 2014, p. 5840-5846.

Research output: Contribution to journalArticle

Cui, X, Belo, S, Krüger, D, Yan, Y, de Rosales, RTM, Jauregui-Osoro, M, Ye, H, Su, S, Mathe, D, Kovács, N, Horváth, I, Semjeni, M, Sunassee, K, Szigeti, K, Green, MA & Blower, PJ 2014, 'Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging', Biomaterials, vol. 35, no. 22, pp. 5840-5846. https://doi.org/10.1016/j.biomaterials.2014.04.004
Cui, Xianjin ; Belo, Salome ; Krüger, Dirk ; Yan, Yong ; de Rosales, Rafael T M ; Jauregui-Osoro, Maite ; Ye, Haitao ; Su, Shi ; Mathe, Domokos ; Kovács, Noémi ; Horváth, I. ; Semjeni, Mariann ; Sunassee, Kavitha ; Szigeti, Krisztian ; Green, Mark A. ; Blower, Philip J. / Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging. In: Biomaterials. 2014 ; Vol. 35, No. 22. pp. 5840-5846.
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