Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

Xianjin Cui, Salome Belo, Dirk Krüger, Yong Yan, Rafael T.M. de Rosales, Maite Jauregui-Osoro, Haitao Ye, Shi Su, Domokos Mathe, Noémi Kovács, Ildikó Horváth, Mariann Semjeni, Kavitha Sunassee, Krisztian Szigeti, Mark A. Green, Philip J. Blower

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56 Citations (Scopus)

Abstract

Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [18F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for 18F-fluoride and 100% for 64Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. Invivo PET imaging showed a slow release of 18F from NPs, but no sign of efflux of 64Cu.

Original languageEnglish
Pages (from-to)5840-5846
Number of pages7
JournalBiomaterials
Volume35
Issue number22
DOIs
Publication statusPublished - Jul 2014

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Keywords

  • Aluminium hydroxide
  • Dual-modal
  • MR
  • Magnetic nanoparticles
  • PET

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Cui, X., Belo, S., Krüger, D., Yan, Y., de Rosales, R. T. M., Jauregui-Osoro, M., Ye, H., Su, S., Mathe, D., Kovács, N., Horváth, I., Semjeni, M., Sunassee, K., Szigeti, K., Green, M. A., & Blower, P. J. (2014). Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging. Biomaterials, 35(22), 5840-5846. https://doi.org/10.1016/j.biomaterials.2014.04.004