Alternatives in hepatoprotection: Cytoprotection- influences on mono-oxidase system - free radical scavengers. (A review)

A. Pár, T. Javor

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Three correlating fields of hepatoprotection have been reviewed: (1) 'classic' gastrointestinal cytoprotection; (2) effects via the mixed function mono-oxidase enzyme system; (3) the role of the free radical scavengers and lipid peroxidation inhibiting agents. Gastrointestinal cytoprotection was originally defined in experimentally induced gastric mucosal injuries where several members of the prostaglandin group proved to be effective. Their capacity to increase the stability of biomembranes can be manifested also in hepatocytes, as PGE2 and PGI2 prevent CCl4-toxicity in experimental animals. Induction of the mono-oxidase system (e.g. with barbiturates or with antioestrogens) may be useful by increasing bilirubin excretion and the biotransformation activity as well as possibly by enhancing protein synthesis in liver cells. Inhibition of the mono-oxidases, on the other hand, can prevent the transformation of toxic substances into even more toxic metabolites and the production of free radicals. Free radical scavengers and inhibitors of lipid peroxidation play a central role in hepatoprotection. A flavonoid substance, (+)-cyanidanol-3, possessing many of the mentioned effects may be a promising alternative in the therapy of liver disease.

Original languageEnglish
Pages (from-to)409-423
Number of pages15
JournalActa Physiologica Hungarica
Volume64
Issue number3-4
Publication statusPublished - 1984

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Free Radical Scavengers
Cytoprotection
Poisons
Oxidoreductases
Barbiturates
Estrogen Receptor Modulators
Catechin
Epoprostenol
Complementary Therapies
Biotransformation
Mixed Function Oxygenases
Bilirubin
Dinoprostone
Flavonoids
Lipid Peroxidation
Free Radicals
Prostaglandins
Liver Diseases
Hepatocytes
Stomach

ASJC Scopus subject areas

  • Physiology

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Alternatives in hepatoprotection : Cytoprotection- influences on mono-oxidase system - free radical scavengers. (A review). / Pár, A.; Javor, T.

In: Acta Physiologica Hungarica, Vol. 64, No. 3-4, 1984, p. 409-423.

Research output: Contribution to journalArticle

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