It is now well established that tumor vasculature is not necessarily derived form endothelial proliferation. In addition to endothelial cell sprouting (proliferation) cancer tissue can acquire its vasculature by incorporation (co-option) of preexisting vessels, intussusceptive microvascular growth, glomeruloid angiogenesis, vasculogenic mimicry, postnatal vasculogenesis (bone marrow-derived endothelial progenitor cells) or combination of these mechanisms. However present day therapies are based exclusively on the sprouting angiogenesis. It must be also considered, that tumor induced angiogenesis can be influenced by connective tissue structure of the target organ and by the degree of differentiation of the tumor. This notion should be taken into consideration when new anti-angiogenic therapies are designed.
|Translated title of the contribution||Alternative vascularization mechanisms in cancer|
|Number of pages||7|
|Publication status||Published - Dec 1 2006|
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