A series of new spiro[N-heterocyclic-adamantanes] was synthesized through the reaction of 2-adamantanone with β-amino carboxamides. Depending on the chemical and physical characteristics of the starting compounds, the cyclocondensations proceeded under simple and mild (aqueous, solvent-free, ball-milling or/and microwave-assisted) conditions with no necessity for chromatographic purification of the products. The reaction was extended to leucinamide and salicylamide.
- Ballmilling reactions
- Environmentally friendly methods
ASJC Scopus subject areas
- Organic Chemistry