Alternative complement pathway activation by CD4+ T cells of HIV infected individuals

A possible role in AIDS pathogenesis

Eitan Yefenof, T. Magyarlaki, Eva maria Fenyo, Britta Wahren, Eva Klein

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The mechanisms by which CD4+ T cells are eliminated during HIV infection are poorly understood. We have previously shown that HIV infected cell lines activate and fix C3 via the alternative complement pathway (ACP). In the present study we examined the ability of blood lymphocytes from 40 HIV+ individuals to fix C3. A large fraction of the CD4+ T cells reacted with anti-gp120 antibodies. These cells also carried C3 fragments in vivo and could further fix C3 if exposed to human serum In vitro. C3 activation occurred via the ACP. In some cases exposure of the lymphocytes to human serum under conditions allowing ACP activation resulted in partial elimination of CD4+ T cells. The results suggest that complement activation and fixation by CD4+ T cells opsonized with HIV particles or gp120 may contribute to their selective destruction.

Original languageEnglish
Pages (from-to)1361-1366
Number of pages6
JournalInternational Immunology
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 1994

Fingerprint

Alternative Complement Pathway
T-cells
Activation
Pathway
Acquired Immunodeficiency Syndrome
Complement
Chemical activation
HIV
T-Lymphocytes
Lymphocytes
Alternatives
HIV Infection
Complement Activation
Cell
Fixation
Serum
Antibody
Antibodies
HIV Infections
Blood

Keywords

  • C3
  • Gp12O
  • T cell depletion

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Transplantation
  • Immunology

Cite this

Alternative complement pathway activation by CD4+ T cells of HIV infected individuals : A possible role in AIDS pathogenesis. / Yefenof, Eitan; Magyarlaki, T.; Fenyo, Eva maria; Wahren, Britta; Klein, Eva.

In: International Immunology, Vol. 6, No. 9, 09.1994, p. 1361-1366.

Research output: Contribution to journalArticle

Yefenof, Eitan ; Magyarlaki, T. ; Fenyo, Eva maria ; Wahren, Britta ; Klein, Eva. / Alternative complement pathway activation by CD4+ T cells of HIV infected individuals : A possible role in AIDS pathogenesis. In: International Immunology. 1994 ; Vol. 6, No. 9. pp. 1361-1366.
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