Alternating current electrospinning for preparation of fibrous drug delivery systems

Attila Balogh, Richárd Cselkó, Balázs Démuth, Geert Verreck, Jürgen Mensch, György Marosi, Zsombor Kristóf Nagy

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Alternating current electrospinning (ACES) was compared to direct current electrospinning (DCES) for the preparation of drug-loaded nanofibrous mats. It is generally considered that DCES is the solely technique to produce nanofibers using the electrostatic force from polymer solutions, however, less studied and also capable ACES provides further advantages such as increased specific productivities. A poorly water-soluble drug (carvedilol) was incorporated into the fibers based on three different polymeric matrices (an acid-soluble terpolymer (Eudragit® E), a base-soluble copolymer (Eudragit® L 100-55) and a nonionic homopolymer (polyvinylpyrrolidone K90)) to improve the dissolution of the weak base drug under different pH conditions. Morphology and fiber diameter evaluation showed similar electrospun fibers regardless the type of the high voltage and the major differences in feeding rates. The amorphous ACES and DCES fibers provided fast and total drug dissolutions in all cases. The presented results show that ACES can be a more feasible novel alternative to formulate fibers for drug delivery purposes.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume495
Issue number1
DOIs
Publication statusPublished - Nov 10 2015

Keywords

  • Alternating current electrospinning
  • Dissolution enhancement
  • Electrospinning
  • Poorly water-soluble drugs
  • Solid dispersion

ASJC Scopus subject areas

  • Pharmaceutical Science

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