Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii

Anita Bufa, Ildikó Bíró, Viktória Poór, Gábor Molnár, Kálmán A. Kovács, A. Felinger, Sára Jeges, F. Kilár, Péter Miklós Göcze

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective.The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated. Design.The urinary concentration of 23 androgen, progesterone and corticoid metabolites was quantitatively determined by gas chromatographymass spectrometry with selected ion-monitoring. We obtained 24-h urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination, we observed changes in the steroid profiles in the disease examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. Results.The concentrations of 16-hydroxy- dehydroepiandrosterone, pregnanediol and pregnenediol were not significantly different in the two groups. The concentrations of androsterone, etiocholanolone, 11β-hydroxy-androsterone, 11β-hydroxy-etiocholanolone, pregnanetriol, pregnenetriol, tetrahydrocortisone, tetrahydro-11-dehydrocorticosterone, tetrahydro-corticosterone, allo-tetrahydro-corticosterone, tetrahydrocortisol, allo-tetrahydrocortisol, α-cortolone, β-cortolone and α-cortol were significantly lower in the postmenopausal women with adenocarcinoma than in the controls. Conclusion.The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalGynecological Endocrinology
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Adenocarcinoma
Steroids
Tetrahydrocortisol
Etiocholanolone
Androsterone
Corticosterone
Androgens
Tetrahydrocortisone
Pregnanetriol
Pregnanediol
Dehydroepiandrosterone
Progesterone
Spectrum Analysis
Adrenal Cortex Hormones
Gases
Urine
Ions
Carcinoma
Control Groups
cortolone

Keywords

  • Adenocarcinoma endometrii
  • Androgens
  • Corticoids
  • Gas chromatographymass spectrometry
  • Progesterone
  • Urinary concentration

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynaecology

Cite this

Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii. / Bufa, Anita; Bíró, Ildikó; Poór, Viktória; Molnár, Gábor; Kovács, Kálmán A.; Felinger, A.; Jeges, Sára; Kilár, F.; Göcze, Péter Miklós.

In: Gynecological Endocrinology, Vol. 26, No. 1, 01.2010, p. 10-15.

Research output: Contribution to journalArticle

Bufa, Anita ; Bíró, Ildikó ; Poór, Viktória ; Molnár, Gábor ; Kovács, Kálmán A. ; Felinger, A. ; Jeges, Sára ; Kilár, F. ; Göcze, Péter Miklós. / Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii. In: Gynecological Endocrinology. 2010 ; Vol. 26, No. 1. pp. 10-15.
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abstract = "Objective.The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated. Design.The urinary concentration of 23 androgen, progesterone and corticoid metabolites was quantitatively determined by gas chromatographymass spectrometry with selected ion-monitoring. We obtained 24-h urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination, we observed changes in the steroid profiles in the disease examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. Results.The concentrations of 16-hydroxy- dehydroepiandrosterone, pregnanediol and pregnenediol were not significantly different in the two groups. The concentrations of androsterone, etiocholanolone, 11β-hydroxy-androsterone, 11β-hydroxy-etiocholanolone, pregnanetriol, pregnenetriol, tetrahydrocortisone, tetrahydro-11-dehydrocorticosterone, tetrahydro-corticosterone, allo-tetrahydro-corticosterone, tetrahydrocortisol, allo-tetrahydrocortisol, α-cortolone, β-cortolone and α-cortol were significantly lower in the postmenopausal women with adenocarcinoma than in the controls. Conclusion.The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.",
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AU - Kovács, Kálmán A.

AU - Felinger, A.

AU - Jeges, Sára

AU - Kilár, F.

AU - Göcze, Péter Miklós

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N2 - Objective.The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated. Design.The urinary concentration of 23 androgen, progesterone and corticoid metabolites was quantitatively determined by gas chromatographymass spectrometry with selected ion-monitoring. We obtained 24-h urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination, we observed changes in the steroid profiles in the disease examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. Results.The concentrations of 16-hydroxy- dehydroepiandrosterone, pregnanediol and pregnenediol were not significantly different in the two groups. The concentrations of androsterone, etiocholanolone, 11β-hydroxy-androsterone, 11β-hydroxy-etiocholanolone, pregnanetriol, pregnenetriol, tetrahydrocortisone, tetrahydro-11-dehydrocorticosterone, tetrahydro-corticosterone, allo-tetrahydro-corticosterone, tetrahydrocortisol, allo-tetrahydrocortisol, α-cortolone, β-cortolone and α-cortol were significantly lower in the postmenopausal women with adenocarcinoma than in the controls. Conclusion.The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.

AB - Objective.The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated. Design.The urinary concentration of 23 androgen, progesterone and corticoid metabolites was quantitatively determined by gas chromatographymass spectrometry with selected ion-monitoring. We obtained 24-h urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination, we observed changes in the steroid profiles in the disease examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. Results.The concentrations of 16-hydroxy- dehydroepiandrosterone, pregnanediol and pregnenediol were not significantly different in the two groups. The concentrations of androsterone, etiocholanolone, 11β-hydroxy-androsterone, 11β-hydroxy-etiocholanolone, pregnanetriol, pregnenetriol, tetrahydrocortisone, tetrahydro-11-dehydrocorticosterone, tetrahydro-corticosterone, allo-tetrahydro-corticosterone, tetrahydrocortisol, allo-tetrahydrocortisol, α-cortolone, β-cortolone and α-cortol were significantly lower in the postmenopausal women with adenocarcinoma than in the controls. Conclusion.The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.

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