Abstract
Objective.The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated. Design.The urinary concentration of 23 androgen, progesterone and corticoid metabolites was quantitatively determined by gas chromatographymass spectrometry with selected ion-monitoring. We obtained 24-h urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination, we observed changes in the steroid profiles in the disease examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. Results.The concentrations of 16-hydroxy- dehydroepiandrosterone, pregnanediol and pregnenediol were not significantly different in the two groups. The concentrations of androsterone, etiocholanolone, 11β-hydroxy-androsterone, 11β-hydroxy-etiocholanolone, pregnanetriol, pregnenetriol, tetrahydrocortisone, tetrahydro-11-dehydrocorticosterone, tetrahydro-corticosterone, allo-tetrahydro-corticosterone, tetrahydrocortisol, allo-tetrahydrocortisol, α-cortolone, β-cortolone and α-cortol were significantly lower in the postmenopausal women with adenocarcinoma than in the controls. Conclusion.The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.
| Original language | English |
|---|---|
| Pages (from-to) | 10-15 |
| Number of pages | 6 |
| Journal | Gynecological Endocrinology |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2010 |
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Keywords
- Adenocarcinoma endometrii
- Androgens
- Corticoids
- Gas chromatographymass spectrometry
- Progesterone
- Urinary concentration
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Obstetrics and Gynaecology
Cite this
Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii. / Bufa, Anita; Bíró, Ildikó; Poór, Viktória; Molnár, Gábor; Kovács, Kálmán A.; Felinger, A.; Jeges, Sára; Kilár, F.; Göcze, Péter Miklós.
In: Gynecological Endocrinology, Vol. 26, No. 1, 01.2010, p. 10-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii
AU - Bufa, Anita
AU - Bíró, Ildikó
AU - Poór, Viktória
AU - Molnár, Gábor
AU - Kovács, Kálmán A.
AU - Felinger, A.
AU - Jeges, Sára
AU - Kilár, F.
AU - Göcze, Péter Miklós
PY - 2010/1
Y1 - 2010/1
N2 - Objective.The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated. Design.The urinary concentration of 23 androgen, progesterone and corticoid metabolites was quantitatively determined by gas chromatographymass spectrometry with selected ion-monitoring. We obtained 24-h urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination, we observed changes in the steroid profiles in the disease examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. Results.The concentrations of 16-hydroxy- dehydroepiandrosterone, pregnanediol and pregnenediol were not significantly different in the two groups. The concentrations of androsterone, etiocholanolone, 11β-hydroxy-androsterone, 11β-hydroxy-etiocholanolone, pregnanetriol, pregnenetriol, tetrahydrocortisone, tetrahydro-11-dehydrocorticosterone, tetrahydro-corticosterone, allo-tetrahydro-corticosterone, tetrahydrocortisol, allo-tetrahydrocortisol, α-cortolone, β-cortolone and α-cortol were significantly lower in the postmenopausal women with adenocarcinoma than in the controls. Conclusion.The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.
AB - Objective.The potential role of androgen metabolism as co-factors in the development of carcinoma endometrii was investigated. Design.The urinary concentration of 23 androgen, progesterone and corticoid metabolites was quantitatively determined by gas chromatographymass spectrometry with selected ion-monitoring. We obtained 24-h urine samples from 13 patients with adenocarcinoma endometrii and from 10 age-matched normal female subjects. In the course of the urinary steroid determination, we observed changes in the steroid profiles in the disease examined compared to the same age and same sex control group. Profiling urinary steroids has to give comprehensive information about the synthesis of steroids including the glandular and peripheral steroid metabolisms. Results.The concentrations of 16-hydroxy- dehydroepiandrosterone, pregnanediol and pregnenediol were not significantly different in the two groups. The concentrations of androsterone, etiocholanolone, 11β-hydroxy-androsterone, 11β-hydroxy-etiocholanolone, pregnanetriol, pregnenetriol, tetrahydrocortisone, tetrahydro-11-dehydrocorticosterone, tetrahydro-corticosterone, allo-tetrahydro-corticosterone, tetrahydrocortisol, allo-tetrahydrocortisol, α-cortolone, β-cortolone and α-cortol were significantly lower in the postmenopausal women with adenocarcinoma than in the controls. Conclusion.The changes in the concentrations of single metabolites point out the important role of steroid group, thus providing help in the recognition and treatment of diseased states.
KW - Adenocarcinoma endometrii
KW - Androgens
KW - Corticoids
KW - Gas chromatographymass spectrometry
KW - Progesterone
KW - Urinary concentration
UR - http://www.scopus.com/inward/record.url?scp=72749127594&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72749127594&partnerID=8YFLogxK
U2 - 10.3109/09513590903159581
DO - 10.3109/09513590903159581
M3 - Article
C2 - 19670000
AN - SCOPUS:72749127594
VL - 26
SP - 10
EP - 15
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
SN - 0951-3590
IS - 1
ER -