Altered protein acetylation in polyglutamine diseases

L. Bodai, J. Pallos, L. M. Thompson, J. L. Marsh

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Polyglutamine diseases are hereditary neurodegenerative disorders caused by the expansion of a CAG repeat in the disease gene. A dominant gain of function is associated with these expanded alleles. The resulting elongated polyglutamine repeats are thought to cause structural changes in the affected proteins, leading to aberrant interactions such as those that allow formation of extra- and intranuclear aggregates. However, self-association is not the only interaction the polyglutamine domain is capable of mediating. Many cellular proteins can be sequestered into inclusions or bound by more soluble forms of the mutant proteins. One group of proteins that binds to and whose activity may be altered by polyglutamines is Histone Acetyltransferases (HATs). HATs are responsible for the acetylation of histones and several other important proteins and this modification results in altered function of the target protein. HATs regulate cellular processes at levels as different as modifying transcriptional competence of chromosomes, temporal regulation of promoter activity and protein activation / inactivation. Recent studies show that the altered balance between protein acetylation and deacetylation may be a key process contributing to expanded polyglutamine-induced pathogenesis. The restoration of this balance is possible by the genetic or pharmacological reduction of the opposing enzyme group, i.e. the Histone Deacetylases (HDACs). Recent progress in HDAC research has made the development of inhibitors of specific HDAC family proteins possible and these compounds could be effective candidates for treatment of these devastating diseases.

Original languageEnglish
Pages (from-to)2577-2587
Number of pages11
JournalCurrent medicinal chemistry
Volume10
Issue number23
DOIs
Publication statusPublished - Dec 5 2003

Keywords

  • HAT
  • HDAC
  • HDAC inhibitors
  • Huntington's disease
  • Neurodegeneration
  • PolyQ
  • Polyglutamine diseases
  • Protein acetylation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Altered protein acetylation in polyglutamine diseases'. Together they form a unique fingerprint.

  • Cite this