Altered organization of GABAA receptor mRNA expression in the depressed suicide brain

Michael O. Poulter, Lisheng Du, Vladimir Zhurov, Miklós Palkovits, Gábor Faludi, Zul Merali, Hymie Anisman

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Inter-relationships ordinarily exist between mRNA expression of GABAA subunits in the frontopolar cortex (FPC) of individuals that had died suddenly from causes other than suicide. However, these correlations were largely absent in persons that had died by suicide. In the present investigation, these findings were extended by examining GABAA receptor expression patterns (of controls and depressed individuals that died by suicide) in the orbital frontal cortex (OFC), hippocampus, amygdala. locus coeruleus (LC) and paraventricular nucleus (PVN), all of which have been implicated in either depression, anxiety or stress responsivity. Using QPCR analysis, we found that in controls the inter-relations between GABAA subunits varied across brain regions, being high in the hippocampus and amygdala, intermediate in the LC, and low in the OFC and PVN. The GABAA subunit inter-relations were markedly different in persons that died by suicide, being reduced in hippocampus and amygdala, stable in the LC, but more coordinated in the OFC and to some extent in the PVN. It seems that altered brain region-specific inhibitory signaling, stemming from altered GABAA subunit coordination, are associated with depression/ suicide. Although, it is unknown whether GABAA subunit re-organization was specifically tied to depression, suicide, or the accompanying distress, these data show that the coordinated expression of this transcriptome does vary depending on brain region and is plastic.

Original languageEnglish
Article number3
JournalFrontiers in Molecular Neuroscience
Volume3
Issue numberMAR
DOIs
Publication statusPublished - Mar 29 2010

Keywords

  • Depression
  • GABA receptors
  • Human
  • Stress
  • Suicide

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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