Altered open field behavior in rats induced by acute administration of 3-nitropropionic acid: Possible glutamatergic and dopaminergic involvement

Anita Lukács, Andrea Szabó, A. Papp, Tünde Vezér

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

3-nitropropionic acid (3-NP), a substance used for modelling Huntington's disease, was given to male Wistar rats in a single 20 mg/kg b.w. dose, and the resulting behavioral alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats' locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioral effect of 3-NP.

Original languageEnglish
Pages (from-to)359-367
Number of pages9
JournalActa biologica Hungarica
Volume60
Issue number4
DOIs
Publication statusPublished - Dec 1 2009

Keywords

  • 3-nitropropionic acid
  • Locomotor activity
  • Open field
  • Rat

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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