Altered expression of Fcγ and complement receptors on b cells in systemic lupus erythematosus

Péter Gergely, Andrea Isaák, Zsuzsanna Szekeres, J. Prechl, A. Erdei, Zsolt B. Nagy, J. Gergely, G. Poór

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell hyper-reactivity, autoantibody production, immune complex (IC) deposition, and multiple organ damage. The contribution of IC and B cell-mediated changes in the pathogenesis of SLE iswell established, however, the exact role of IC-binding receptors expressed on B cells, Fcγ receptors, and complement receptors CR1 and CR2 in these pathological processes is unclear. Development of lupus-like symptoms in mice defective for the inhibitory FcγRIIb and genetic association of certain FcγR genes with SLE demonstrate a significant role for these receptors but reports indicating alterations of Fcγ or complement receptor-mediated B cell functions in human SLE are relatively few. The present review highlights a selected set of data including our own discussing the significance of animal models, genetics, and functional alterations of these IC-binding receptors in the etiopathogenesis of SLE.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages183-192
Number of pages10
Volume1108
DOIs
Publication statusPublished - Jun 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1108
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Complement Receptors
Fc Receptors
Antigen-Antibody Complex
Systemic Lupus Erythematosus
Cells
B-Lymphocytes
Autoantibodies
Pathologic Processes
Animals
Genes
Autoimmune Diseases
Chronic Disease
Animal Models

Keywords

  • B cell
  • Complement receptor
  • Fcγ receptor
  • SLE

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gergely, P., Isaák, A., Szekeres, Z., Prechl, J., Erdei, A., Nagy, Z. B., ... Poór, G. (2007). Altered expression of Fcγ and complement receptors on b cells in systemic lupus erythematosus. In Annals of the New York Academy of Sciences (Vol. 1108, pp. 183-192). (Annals of the New York Academy of Sciences; Vol. 1108). https://doi.org/10.1196/annals.1422.020

Altered expression of Fcγ and complement receptors on b cells in systemic lupus erythematosus. / Gergely, Péter; Isaák, Andrea; Szekeres, Zsuzsanna; Prechl, J.; Erdei, A.; Nagy, Zsolt B.; Gergely, J.; Poór, G.

Annals of the New York Academy of Sciences. Vol. 1108 2007. p. 183-192 (Annals of the New York Academy of Sciences; Vol. 1108).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gergely, P, Isaák, A, Szekeres, Z, Prechl, J, Erdei, A, Nagy, ZB, Gergely, J & Poór, G 2007, Altered expression of Fcγ and complement receptors on b cells in systemic lupus erythematosus. in Annals of the New York Academy of Sciences. vol. 1108, Annals of the New York Academy of Sciences, vol. 1108, pp. 183-192. https://doi.org/10.1196/annals.1422.020
Gergely P, Isaák A, Szekeres Z, Prechl J, Erdei A, Nagy ZB et al. Altered expression of Fcγ and complement receptors on b cells in systemic lupus erythematosus. In Annals of the New York Academy of Sciences. Vol. 1108. 2007. p. 183-192. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1422.020
Gergely, Péter ; Isaák, Andrea ; Szekeres, Zsuzsanna ; Prechl, J. ; Erdei, A. ; Nagy, Zsolt B. ; Gergely, J. ; Poór, G. / Altered expression of Fcγ and complement receptors on b cells in systemic lupus erythematosus. Annals of the New York Academy of Sciences. Vol. 1108 2007. pp. 183-192 (Annals of the New York Academy of Sciences).
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