Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus

L. Madácsy, L. Barkai, A. Sánta, D. Krikovszky

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: The recently observed increase in the incidence of type 1 diabetes mellitus (Type 1 DM) suggests a major role of environmental factors in the etiopathogenesis of the disease. The individual variation in cytochrome P450IID6 may influence the individual susceptibility to environmentally linked diseases. We aimed to evaluate the prevalence of cytochrome P450IID6 phenotypes in Hungarian children with Type 1 DM (n = 69) compared to healthy controls (n = 100). Methods: Debrisoquine was administered orally and debrisoquine hydroxylation phenotype was determined as a metabolic ratio of urinary recovered debrisoquine and 4-hydroxydebrisoquine. Results: Eight of the 100 healthy subjects (8%) and 15 of the 69 diabetic children (22%) (p < 0.05) had cytochrome P450IID6 poor metabolizer phenotype (metabolic ratio ≥12.6). Conclusion: Cytochrome P 450IID6's activity may play a role in the development of Type 1 DM.

Original languageEnglish
Pages (from-to)176-179
Number of pages4
JournalHormone research
Volume61
Issue number4
DOIs
Publication statusPublished - Apr 16 2004

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Keywords

  • Cytochrome PIID6
  • Debrisoquine
  • Phenotype
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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