Altered crosstalk in the dipeptidyl peptidase-4-incretin-immune system in type 1 diabetes: A hypothesis generating pilot study

András Zóka, G. Barna, Orsolya Hadarits, Zahra Al-Aissa, Barna Wichmann, G. Müzes, A. Somogyi, G. Firneisz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Both GLP17 - 36 (via GLP1 receptor) and the dipeptidyl peptidase-4 (DPP4) cleaved form of GLP1 (GLP19 - 36, independently of GLP1R) may modulate the response of lymphocytes to cytokine stimuli. The incretin axis, CXCR3 (receptor of DPP4 ligand cytokines CXCL9-11) expression on Tregs and hematologic parameters were assessed in 34 patients with long standing type 1 diabetes (T1DM) and in 35 healthy controls. Serum DPP4 (sDPP4) activity, plasma total GLP1 and GLP17 - 36 concentrations were determined. GLP19 - 36 concentrations were calculated. CXCR3 expression (flow cytometry) was higher on the CD25-/ lowFoxp3+ than on the CD25+Foxp3+ Tregs independently from T1DM, suggesting that CD25-/ lowFoxp3+ Tregs are possibly waiting for orientational chemotactic stimuli in a "standby mode". The higher sDPP4 activities in T1DM were inversely correlated with GLP17 - 36 levels and GLP19 - 36 levels directly with lymphocyte counts in controls. Our results might indicate an altered DPP4-incretin system and altered immunoregulation including a potentially dysfunctional GLP19 - 36 signaling in T1DM.

Original languageEnglish
Pages (from-to)667-672
Number of pages6
JournalHuman Immunology
Volume76
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Dipeptidyl Peptidase 4
Incretins
Type 1 Diabetes Mellitus
Immune System
CXCR3 Receptors
Cytokines
Lymphocyte Count
Serum
Flow Cytometry
Lymphocytes
Ligands

Keywords

  • CXCR3
  • DPP4
  • GLP1
  • T
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Altered crosstalk in the dipeptidyl peptidase-4-incretin-immune system in type 1 diabetes : A hypothesis generating pilot study. / Zóka, András; Barna, G.; Hadarits, Orsolya; Al-Aissa, Zahra; Wichmann, Barna; Müzes, G.; Somogyi, A.; Firneisz, G.

In: Human Immunology, Vol. 76, No. 9, 01.09.2015, p. 667-672.

Research output: Contribution to journalArticle

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