Alterations of primary haemostasis in mixed connective tissue disease (MCTD)

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Willebrand-factor antigen level and structure analysis, ristomycin-cofactor assay, beta-thromboglobulin and thromboxane metabolite estimations were performed in 22 patients with mixed connective tissue disease to evaluate the incidence and the possible role of haemostatic alterations in the complications occurring during the course of the disease. High levels of Willebrand-factor antigen and ristomycin-cofactor acitivity were detected in patients with thrombocytopenia, previous thrombotic event, pulmonary vascular lesions and usually in the presence of circulating anti-endothelial antibodies. Increased platelet activation could have been found in antibody positive cases and in patients with thrombocytopenia as well. The documented alterations of endothelial and platelet funtions may play important role in the vascular complications of mixed connective tissue disease.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalThrombosis Research
Volume63
Issue number3
DOIs
Publication statusPublished - Aug 1 1991

Fingerprint

Mixed Connective Tissue Disease
Hemostasis
Ristocetin
Thrombocytopenia
Blood Vessels
beta-Thromboglobulin
Thromboxanes
Platelet Activation
Hemostatics
Anti-Idiotypic Antibodies
Blood Platelets
Lung
Antibodies
Incidence
Von Willebrand antigen

Keywords

  • anti-endothelial antibodies
  • Mixed connective tissue disease
  • platelet activation
  • Willebrand factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Alterations of primary haemostasis in mixed connective tissue disease (MCTD). / Udvardy, M.; Bodolay, E.; Szegedi, G.; Hársfalvi, J.; Boda, Z.; Rak, K.

In: Thrombosis Research, Vol. 63, No. 3, 01.08.1991, p. 281-286.

Research output: Contribution to journalArticle

@article{3cad97faeb09461795ae42907bb62a1e,
title = "Alterations of primary haemostasis in mixed connective tissue disease (MCTD)",
abstract = "Willebrand-factor antigen level and structure analysis, ristomycin-cofactor assay, beta-thromboglobulin and thromboxane metabolite estimations were performed in 22 patients with mixed connective tissue disease to evaluate the incidence and the possible role of haemostatic alterations in the complications occurring during the course of the disease. High levels of Willebrand-factor antigen and ristomycin-cofactor acitivity were detected in patients with thrombocytopenia, previous thrombotic event, pulmonary vascular lesions and usually in the presence of circulating anti-endothelial antibodies. Increased platelet activation could have been found in antibody positive cases and in patients with thrombocytopenia as well. The documented alterations of endothelial and platelet funtions may play important role in the vascular complications of mixed connective tissue disease.",
keywords = "anti-endothelial antibodies, Mixed connective tissue disease, platelet activation, Willebrand factor",
author = "M. Udvardy and E. Bodolay and G. Szegedi and J. H{\'a}rsfalvi and Z. Boda and K. Rak",
year = "1991",
month = "8",
day = "1",
doi = "10.1016/0049-3848(91)90131-F",
language = "English",
volume = "63",
pages = "281--286",
journal = "Thrombosis Research",
issn = "0049-3848",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Alterations of primary haemostasis in mixed connective tissue disease (MCTD)

AU - Udvardy, M.

AU - Bodolay, E.

AU - Szegedi, G.

AU - Hársfalvi, J.

AU - Boda, Z.

AU - Rak, K.

PY - 1991/8/1

Y1 - 1991/8/1

N2 - Willebrand-factor antigen level and structure analysis, ristomycin-cofactor assay, beta-thromboglobulin and thromboxane metabolite estimations were performed in 22 patients with mixed connective tissue disease to evaluate the incidence and the possible role of haemostatic alterations in the complications occurring during the course of the disease. High levels of Willebrand-factor antigen and ristomycin-cofactor acitivity were detected in patients with thrombocytopenia, previous thrombotic event, pulmonary vascular lesions and usually in the presence of circulating anti-endothelial antibodies. Increased platelet activation could have been found in antibody positive cases and in patients with thrombocytopenia as well. The documented alterations of endothelial and platelet funtions may play important role in the vascular complications of mixed connective tissue disease.

AB - Willebrand-factor antigen level and structure analysis, ristomycin-cofactor assay, beta-thromboglobulin and thromboxane metabolite estimations were performed in 22 patients with mixed connective tissue disease to evaluate the incidence and the possible role of haemostatic alterations in the complications occurring during the course of the disease. High levels of Willebrand-factor antigen and ristomycin-cofactor acitivity were detected in patients with thrombocytopenia, previous thrombotic event, pulmonary vascular lesions and usually in the presence of circulating anti-endothelial antibodies. Increased platelet activation could have been found in antibody positive cases and in patients with thrombocytopenia as well. The documented alterations of endothelial and platelet funtions may play important role in the vascular complications of mixed connective tissue disease.

KW - anti-endothelial antibodies

KW - Mixed connective tissue disease

KW - platelet activation

KW - Willebrand factor

UR - http://www.scopus.com/inward/record.url?scp=0025834942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025834942&partnerID=8YFLogxK

U2 - 10.1016/0049-3848(91)90131-F

DO - 10.1016/0049-3848(91)90131-F

M3 - Article

VL - 63

SP - 281

EP - 286

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 3

ER -