Alterations of P53 and RB genes and the evolution of the accelerated phase of chronic myeloid leukemia

Zoltán Beck, Attila Kiss, Ferenc D. Tóth, Judit Szabó, Attila Bácsi, Erzsébet Balogh, Ágnes Borbély, Béla Telek, Eszter Kovács, Éva Oláh, Kalman Rak

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Abstract

Using the single-strand conformation polymorphism and heteroduplex analyses, the P53 and RB genes were analyzed in cell samples from twenty-eight patients with chronic myeloid leukemia (CML) both at diagnosis and at the onset of accelerated phase (AP) of the disease. No alterations of the P53 or RB genes were found in any of the chronic phase (CP) samples. Structural abnormalities of the P53 gene were observed in ten of twenty-eight AP samples within exons 4, 5, 7 and 9. Of the ten cases of AP disease with altered P53 genes, five patients also suffered from the deletion of the other allele. Alterations of the RB gene could be detected in six AP samples, and aberrant band patterns were found in the analysis of exons 2, 3, 4, 6, 7, 13, 14, 17, 21 and 26. Among the six AP samples with structural abnormalities of the RB gene, two showed the loss of the other allele. It is of note that alterations of both P53 and RB genes were observed in two AP samples. Our data strongly suggest that abnormalities of the P53 and RB genes and acceleration of CML are linked events in some cases of AP.

Original languageEnglish
Pages (from-to)587-597
Number of pages11
JournalLeukemia and Lymphoma
Volume38
Issue number5-6
DOIs
Publication statusPublished - Jan 1 2000

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Keywords

  • Acceleration
  • Chronic myeloid leukemia
  • P53 and RB gene alterations

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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