Alterations of glucocorticoid receptor expression during glucocorticoid hormone therapy in renal transplant patients

T. Berki, Afshin Tavakoli, Károly Kalmár Nagy, Gergely Nagy, P. Németh

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Previous studies have demonstrated that glucocorticoid resistance develops in some patients during glucocorticoid therapy due to the down-regulation of glucocorticoid receptor (GCR) expression. A new flow cytometric method has been used for monitoring the intracellular GCR level in peripheral blood mononuclear cells (PBMCs). GCR expression by different lymphocyte subpopulations (bearing surface CD4+ CD8+ or CD19+) in steroid-treated (ST) and nontreated (NT) renal transplant patients was also compared. High, decreasing-dose steroid treatment caused a reduced GCR expression in 50% of the renal transplant patients. Long-lasting, low-dose steroid therapy caused a fall in GCR level in only 11% of patients. CD4+ T lymphocytes showed both the lowest GCR level and its alteration due to steroid therapy, while CD8+ T cells and CD19+ B lymphocytes expressed higher GCR levels and were more sensitive to steroid treatment. Detection of GCR expression in lymphocytes may provide useful information about the changes of glucocorticoid sensitivity during the therapy.

Original languageEnglish
Pages (from-to)132-138
Number of pages7
JournalTransplant International
Volume15
Issue number2-3
DOIs
Publication statusPublished - 2002

Fingerprint

Glucocorticoid Receptors
Glucocorticoids
Hormones
Transplants
Kidney
Steroids
Therapeutics
T-Lymphocytes
Lymphocyte Subsets
Blood Cells
B-Lymphocytes
Down-Regulation
Lymphocytes

Keywords

  • Flow cytometry
  • Glucocorticoid receptor
  • Glucocorticoid therapy
  • Kidney transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Alterations of glucocorticoid receptor expression during glucocorticoid hormone therapy in renal transplant patients. / Berki, T.; Tavakoli, Afshin; Nagy, Károly Kalmár; Nagy, Gergely; Németh, P.

In: Transplant International, Vol. 15, No. 2-3, 2002, p. 132-138.

Research output: Contribution to journalArticle

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AU - Németh, P.

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