Alterations of conditioned taste aversion after microiontophoretically applied neurotoxins in the medial prefrontal cortex of the rat

I. Hernádi, Zoltán Karádi, József Vígh, Zoltán Petykó, Róbert Egyed, Beáta Berta, L. Lénárd

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The prefrontal cortex (PFC) has been reported to be essential in neural control of feeding. In the present study, we aimed to provide a complex characterization of behavioral consequences of PFC microlesions in CFY rats. Kainic acid (KA) was microiontophoretically applied into the mediodorsal division of PFC to damage intrinsic neurons, whereas in another group of rats, 6-hydroxydopamine (6-OHDA) was microiontophoretized into the same region to destroy catecholaminergic (CA) projection fiber terminals. Body weights, food and fluid intake of both lesioned and (sham-operated or intact) control animals were daily measured. Effects of intracellular dehydration and water deprivation were also studied. Open field activity, stereotyped behaviors, and orientation towards visual and somesthetic stimuli were pre- and postoperatively tested. To examine hypothesized consequences of mPFC microlesions on central taste information processing, the acquisition and retention of saccharine conditioned taste aversion (CTA) were studied. No major changes were recorded in body weights, food and water consumption. Dehydration or deprivation similarly increased water intake in all animals. Scores of open field activity and stereotyped behaviors in the 6-OHDA group were significantly higher than those of the other groups. As the main findings of the present studies, both KA and 6-OHDA lesioned rats displayed significant deficits in CTA acquisition and retention tests. These results suggest that the medial PFC has a substantial role in both the formation and the retrieval of CTA. Furthermore, the present findings also indicate the general significance of prefrontal CA mechanisms in the organization of goal-directed, adaptive behaviors.

Original languageEnglish
Pages (from-to)751-758
Number of pages8
JournalBrain Research Bulletin
Volume53
Issue number6
DOIs
Publication statusPublished - 2000

Fingerprint

Oxidopamine
Neurotoxins
Prefrontal Cortex
Stereotyped Behavior
Kainic Acid
Dehydration
Drinking
Body Weight
Water Deprivation
Body Water
Psychological Adaptation
Body Fluids
Automatic Data Processing
Eating
Neurons
Food

Keywords

  • Gustatory learning
  • Microiontophoretic lesion
  • Prefrontal cortex
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alterations of conditioned taste aversion after microiontophoretically applied neurotoxins in the medial prefrontal cortex of the rat. / Hernádi, I.; Karádi, Zoltán; Vígh, József; Petykó, Zoltán; Egyed, Róbert; Berta, Beáta; Lénárd, L.

In: Brain Research Bulletin, Vol. 53, No. 6, 2000, p. 751-758.

Research output: Contribution to journalArticle

Hernádi, I. ; Karádi, Zoltán ; Vígh, József ; Petykó, Zoltán ; Egyed, Róbert ; Berta, Beáta ; Lénárd, L. / Alterations of conditioned taste aversion after microiontophoretically applied neurotoxins in the medial prefrontal cortex of the rat. In: Brain Research Bulletin. 2000 ; Vol. 53, No. 6. pp. 751-758.
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